Environmental Health Sciences 
Environmental Toxicology Training Grant - Faculty
Supported by the National Institute of Environmental Health Sciences, NIH
Stuart Batterman, PhD
Professor and Associate Chair, Department of Environmental Health Sciences,
School of Public Health
Email: stuartb@umich.edu
Exposure assessment, biological monitoring, human health risk and environmental
impact assessment; innovative measurement techniques for air pollutants.
Robert Daniel Brook, MD
Associate Professor, Department of Internal Medicine, Cardiology, Medical School.
Email: robdbrok@umich.edu
Health effects and mechanisms of cardiovascular disease related to air polution; mechanisms of obesity and metabolic syndrome-related vascular dysfunction; ultrasound-based and novel atherosclerosis imaging techniques; human vascular physiology; human blood pressure monitoring; global cardiovascular risk assessment and prevention.
Robert
Denver, PhD
Associate Professor and Associate Chair, Department of Molecular, Cellular,
and Developmental Biology, College of Literature Sciences and Arts; Assistant
Research Scientist, Reproductive Sciences Program
Email: rdenver@umich.edu
Neuroendocrine control of development and hormone action in brain development; environmental stress and its impacts on development; epigenetic modifications caused by stress hormones and activated by changes in the environment.
John K. Fink, M.D.
Professor, Department of Neurology, Medical School
Email: jkfink@umich.edu
Genetics of neurologic and psychiatric disorders; gene-environment interactions to elucidate gene variations that confer susceptibility to environmental toxins in general and organophosphorous compounds in particular.
Alfred Franzblau, MD
Professor, Environmental Health Sciences; Associate Professor, Emergency Medicine; Associate Research Scientist, Center for Ergonomics
Email: afranz@umich.edu
Work-related musculoskeletal disorders, biological monitoring of chemical exposures, occupational neurological disease, occupational respiratory disease and environmental exposure assessment for dioxins and other persistent environmental chemicals.
Ari Gafni, Ph.D.
Professor, Department of Biological Chemistry
Research Professor, Biophysics Research Division
Research Professor, Institute of Gerontology
Email: arigafni@umich.edu
Age related conformational modifications in proteins; structural alterations that occur in transcription factors (e.g., Heat Shock Factor I) in response to aging and/or chemical or other stressors. Advanced methods of structural protein chemistry.
Craig Harris, PhD
Professor, Department of Environmental Health Sciences, School of Public
Health
Email: charris@umich.edu
Mammalian developmental toxicology and biochemical mechanisms of teratogenesis;
the role of biochemical defenses in the developing rat conceptus that
influence the incidence and severity of dysmorphogenesis.
Paul F. Hollenberg,
PhD, DSc
Professor and Chair, Department of Pharmacology, Medical School
Email: hollenberg@umich.edu
Cytochrome P450s; mechanisms by which cells activate environmental
chemicals to reactive forms that cause cancer; development of selective
P450 inactivators for the prevention of human cancers; elucidation of
structures & key catalytic residues of active sites of human P450s.
Howard Hu, MD, MPH, ScD
NSF Internation Departmnet Chair, Environmental Health Sciences; Professor and Chair, Environmental Health Sciences; Professor of Epidemiology; Professor of Internal Medicine, Medical School
Email: howardhu@umich.edu
Environmental epidemiology, heavy metals, gene-environment and epigenetic-environment interactions; nutrient-toxicant interactions; early life origins of chronic disease; children's environmental health; hypertension, renal dysfunction, cognitive declines, Parkinson's Disease, Alzheimer's Disease, neurodevelopment; environment, chemical sensitivities, global climate change and health.
Sharon Kardia, PhD
Associate Professor, Epidemiology
Email: skardia@umich.edu
Genetic epidemiology of cardiovascular disease and its risk factors; gene-environment and gene-gene interactions; development of novel analytical strategies to understand complex relationships between genetic variation, environmental variation, and risk of common chronic diseases.
Richard Keep,
PhD
Senior Associate Professor, Department of Physiology; Research Scientist,
Department of Neurosurgery, Medical School
Email: rkeep@umich.edu
Blood-brain and blood-CSF barrier transport of nutrients, hormones
and toxic agents, including identification and characterization of transporters,
how diseases alter these processes, and how altered transport affects
the clearance of endogenous and exogenous neurotoxic substances.
Raoul
Kopelman, PhD
Kasinir Fajans Collegiate Professor of Chemistry, Physics & Applied
Physics, Department of Chemistry, College of Literature Sciences &
Arts
Email: kopelman@umich.edu
Development of intracellular biochemical and biophysical nanosensors
for measurement of chemically-induced injury in cells, tissues and organs.
Theodore
S. Lawrence, MD, PhD
Professor and Chair, Department of Radiation Oncology, Medical School;
Professor of Toxicology, Department of Environmental Health Sciences,
School of Public Health
Email: tsl@umich.edu
Utilization of a gene therapy enzyme/pro-drug strategy to target delivery
of the radiosensitizing drug 5-fluorouracil (5-FU) in the treatment of
liver metastases; mechanisms of radiosensitization by fluoropyrimidines
such as Gemcitabine in pancreas cancer; cell cycle changes and
the apoptotic pathway; study of an inhibitor of the epidermal growth factor
receptor family as a potential radiosensitizing agent.
Mats Ljungman,
PhD
Associate Professor, Department of Radiation Oncology, Medical School;
Associate Professor of Toxicology, Department of Environmental Health
Sciences, School of Public Health
Email: ljungman@umich.edu
Mechanisms of DNA damage signaling in human cells; DNA repair mechanisms
and other mechanisms that arrest proliferating cells at cell cycle checkpoints;
role of DNA damage & repair in apoptosis.
Rita Loch-Caruso, PhD
Professor, Department of Environmental Health Sciences, School of Public
Health; Associate Research Scientist, Reproductive Sciences Program
Email: rlc@umich.edu
Reproductive and developmental toxicology; molecular, cellular and pathophysiologic mechanisms
of abnormal parturition; toxicant effects on placenta and extraplacental membranes; preterm birth and dysfunctional labor.
David Lubman, Ph.D.
Professor, Department of Chemistry
Email: dmlubman@umich.edu
Use of 2-D liquid separation to rapidly profile highly expressed proteins from breast cancer cell lines; development of methods for microsequencing in an ion trap/reTOF device. Proteomics technologies.
Peter Mancuso, PhD, MS
Associate Professor, Environmental Health Sciences
Email: pmancuso@umich.edu
Role of leptin in pulmonary inflammation; macrophage biology; host defense against pneumococcal pneumonia; tobacco smoke exposure; and pulmonary immune suppression.
Jeffrey Randall Martens, PhD
Assistant Professor, Pharmacology
Email: martensj@umich.edu
Membrane organization of signal transduction pathways including mechanisms of cilia transport in olfactory sensory neurons, olfactory disorders related to cilia, and ion channels in the cardiovascular system.
Jerome Nriagu, PhD, DSc
Professor, Department of Environmental Health Sciences, School of Public
Health
Email: jnriagu@umich.edu
Sources, fate and health effects of toxic metals in the environment;
environmental food contamination; water quality issues in the Great Lakes;
environmental justice and environmental health in developing countries.
Marie O'Neill, PhD
Assistant Professor, Environmental Health Sciences
Email: marieo@umich.edu
Health effects of air pollution, temperature extremes and climate change (mortality, asthma, hospital admissions, birth outcomes and cardiovascular endpoints); environmental exposure assessment; and socio-economic influences on health.
Yoichi Osawa,
PhD
Associate Professor, Department of Pharmacology, Medical School
Email:osawa@umich.edu
Free radicals, oxidative stress and tissue injury; mechanisms of inactivation
of nitric oxide synthase by xenobiotics, including drugs, components of
tobacco smoke and environmental agents.
Vasantha
Padmanabhan, PhD
Senior Research Scientist, Departmental of Pediatrics & Communicable
Diseases, Medical School; Senior Research Scientist, Reproductive Sciences
Program
Email: vasantha@umich.edu
Prenatal programming of reproductive and metabolic functions; neuroendocrine, pituitary paracrine and ovarian control of reproduction; impact of environmental estrogens on fertility.
Vincent L. Pecoraro, PhD
John T. Groves Collegiate Professor of Chemistry, Department of Chemistry, College of Literature, Sciences and the Arts, and Director, Chemistry Biology Interface Training Program
Email: vlpec@umich.edu
Study of the molecular basis for heavy metal (Pb)II), Hg(II), Cd(II) and As (III)) uptake, transport, toxicity and detoxification in bacteria and humans. Development of protein based sequestrian agents for these elements.
Karen Peterson, DSc
Professor, Environmental Health Sciences
Email: karenep@umich.edu
Nutritional determinants of intergenerational patterns of growth in mothers and children; design and evaluation of domestic and international nutrition surveillance systems, and community-based nutrition interventions in low-income, multi-ethnic populations.
Martin A. Philbert, PhD
Associate Professor and Associate Chair, Department of Environmental Health
Sciences, School of Public Health
Email: philbert@umich.edu
Experimental neuropathology, nito-compound-induced encephalopathies,
mitochondrial mechanisms in non-neuronal cell death, development of nano-optical
chemical systems, and nanostructure-based imaging of tumors of the head
and neck.
Bruce
C. Richardson, PhD
Professor, Department of Internal Medicine, Medical School
Email: brichard@umich.edu
Chromatin structure in autoimmunity, cancer and aging, with a particular emphasis on the role of altered chromatin structure in the pathogenesis of human lupus; impact of the environment on chromatin structure in lupus; development of new techniques to assess biomarkers for lupus activity; identification of molecular targets for lupus therapeutic interventions.
Rudy J. Richardson, ScD,
DABT
Professor , Department of Environmental Health Sciences, School of Public
Health; Associate Professor, Department of Neurology, Medical School
Email: rjrich@umich.edu
Neural injury with applications to neurodegenerative disease and stroke;
biomarkers of neurotoxicant exposure, dysfunction and recovery; stereochemistry
and structure-activity relationships; chemistry and neurotoxicity of organophosphorus
and other inhibitors of serine esterases and proteases; risk assessment
and policy.
Thomas G. Robins, MD, MPH
Professor, Department of Environmental Health Sciences, School of Public
Health, Assistant Professor, Department of Internal Medicine, Medical
School
Email: trobins@umich.edu
Exposure assessment and disease outcomes, epidemiology of inhaled toxins
(coal dust, lead, allergens and ambient air pollutants, metalworking fluid
aerosols, DDT); information transfer.
Brian
D. Ross, PhD
Professor, Department of Radiology, Medical School; Professor, Department
of Biological Chemistry, Medical School
Email: bdross@umich.edu
Monitoring and testing of cytotoxic or tumorigenic compounds on intact
biological systems with noninvasive imaging methods.
Laura Rozek, PhD
Assistant Professor, Environmental Health Sciences
Email: rozekl@umich.edu
Population studies of genetic and environmental causes of common cancer in humans; the role of epigenetics in the etiology and prognosis of human cancer; the interplay between the environment and epigenome in common diseases.
Jochen
H. Schacht, PhD
Professor, Department of Biological Chemistry, Medical School; Professor,
Department of Otorhinolaryngology; Medical School; Director, Kresge Hearing
Research Institute, Medical School
Email: schacht@umich.edu
Neurotoxins; toxicant-induced hearing loss; antioxidant therapy for
the prevention of toxicant-induced hearing loss.
David Johnson States, MD, PhD
Professor, Human Genetics
Email: dstates@umich.edu
Computational methods to understand eukaryotic genome function with a particular interest in the control of gene expression in the myeloid immune system.
Jeanne Stuckey, PhD
Research Assistant Professor, Biological Chemistry Department; Research Assistant Professor, Biophysics Research Division; Research Assistant Professor, Life Sciences Institute
Email: jass@umich.edu
Structure-based drug design to develop new cancer therapies; toxicant modification of structure-function relationships of membrane-modifying enzymes that are involved in a variety of diseases such as cancer, diabetes and neuropathies.
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