Publications

Recent Trainee Publications (past five years)

Akella SS, Beck MJ, Philbert MA, Harris C (2000) Comparison of in vitro and in utero ethanol exposure on indices of oxidative stress. In Vitro Mol Toxicol 13:281-296.

Akella SS, Harris C (1999) Pyridine nucleotide flux and glutathione oxidation in the cultured rat conceptus. Reprod Toxicol 13:203-213.

Akella SS, Harris C (2001) Developmental ontogeny of NAD+ kinase in the rat conceptus. Toxicol Appl Pharmacol 170:124-129.

Ambroso JL, Larsen SJV, Brabec RK, Harris C (1997) Fluorometric analysis of endocytosis and lysosomal proteolysis in the rat visceral yolk sac during whole embryo culture. Teratology 56: 201-209.

Beck MJ, McLellan C, Lightle RL, Philbert MA, Harris C (2001) Spatial glutathione and cysteine distribution and chemical modulation in the early organogenesis-stage rat conceptus in utero. Toxicol Sci 62:92-102.

Bestervelt LL, Pitt JA, Nolan CJ, Cai Y, Piper DW, Dybowski JA, Dayharsh GA, Piper WN (1998) In vitro 2,3,7,8-tetrachlorodibenzo-p-dioxin interference with the anterior pituitary hormone adrenocorticortropin. Toxicol Sci 44:107-115.

Bestervelt LL, Pitt JA, Piper WN (1998) Evidence for Ah receptor mediation of increased ACTH concentrations in primary cultures of rat anterior pituitary cells exposed to TCDD. Toxicol Sci 46:294-299.

Billecke SS, Primo-Parmo SL, Dunlop CS, Doorn JA, La Du BN, Broomfield CA (1999) Characterization of a soluble mouse liver enzyme capable of hydrolyzing diisopropyl phosphofluoridate. Chem Biol Interact 119-120: 251-256.

Brasuel M, Kopelman R, Miller TJ, Tjalkens R, Philbert MA (2001) Fluorescent nanosensors for intracellular chemical analysis: decyl methacrylate liquid polymer matrix and ion-exchange-based potassium PEBBLE sensors with real-time application to viable rat C6 glioma cells. Anal Chem 73:2221-2228.

Brasuel M, Kopelman R, Miller TJ, Tjalkens R, Philbert MA (2001) Fluorescent nanosensors for intracellular chemical analysis: decyl methacrylate liquid polymer matrix and ion exchange based potassium PEBBLE sensors with real time application to viable rat C6 glioma cells. Anal Chem 73: 2221 2228.

Choe H-S, Hansen JM, Harris C (2001) Spatial and temporal ontogenies of antioxidant enzyme activities during development of the prenatal rat. J Biochem Mol Toxicol 15: 197-206.

Clark HA, Tjalkens R, Philbert MA, Kopelman R (1999) Optical nanosensors for chemical analysis inside single living cells. Part II: Sensors specific for pH and calcium and the intracellular application of PEBBLE sensors. Ana Chem 71: 4837 4843.

Criswell KA, Loch-Caruso R (1999) Lindane-induced inhibition of spontaneous contractions of pregnant rat uterus. Biol Repro 13: 481-490.

Doorn JA, Gage DA, Schall M, Talley TT, Thompson CM, Richardson RJ (2000) Inhibition of acetylcholinesterase by (1S,3S)-isomalathion proceeds with loss of thiomethyl: Kinetic and mass spectral evidence for an unexpected primary leaving group. Chem Res Toxicol 13: 1313-1320.

Doorn JA, Schall M, Gage DA, Talley TT, Thompson CM, Richardson RJ (2001) Identification of butyrylcholinesterase adducts after inhibition with isomalathion using mass spectrometry: Difference in mechanism between (1R) and (1S) stereoisomers. Toxicol Appl Pharmacol 176: 73-80.

Doorn JA, Sorenson RC, Billecke SS, Hsu C, La Du, BN (1999) Evidence that several conserved histidine residues are required for hydrolytic activity of human paraoxonase/arylesterase. Chem Biol Interact 119-120: 235-241.

Doorn JA, Talley TT, Thompson CM, Richardson RJ (2001) Probing the active sites of butyrylcholinesterase and cholesterol esterase with isomalathion: Conserved stereoselective inactivation of serine hydrolases structurally related to acetylcholinesterase. Chem Res Toxicol 14: 807-813.

Hanna IH, Reed JR, Guengerich FP, Hollenberg PF (2000) Expression of human cytochrome P450 2B6 in Escherichia coli: characterization of catalytic activity and expression levels in human liver. Arch Biochem Biophys 376:206-216.

Hansen JM, Carney EW, Harris C (1999) Differential alteration by thalidomide of the glutathione content of rat vs. rabbit conceptuses in vitro. Reprod Toxicol 13: 547-554.

Hansen JM, Carney EW, Harris C (2001) Alterations in differentiation in the rat and rabbit limb bud micromass culture by glutathione modulating agents. Free Rad Biol Med 31: 1582-1592.

Hansen JM, Choe H-S, Carney EW, Harris C (2001) Differential antioxidant enzyme activities and glutathione content between rat and rabbit conceptuses. Free Radical Biology and Medicine 30: 1078-1088.

Hansen JM, Harris C (2002) Thalidomide alters redox status and selectively alters glutathione in rabbit vs. rat embryonic limb bud cells. J Pharmacol Exper Ther 300: 768-776.

Jiang Y, Kuo CL, Pernecky SJ, Coon MJ, Piper WN (1998) Cytochrome P450 2E1 mRNA in the rat prostate: Detection and quantitation by competitive reverse transcription and polymerase chain reaction. Molec Cell Probes 12: 263-271.

Jiang Y, Kuo CL, Pernecky SJ, Piper WN (1998) The detection of cytochrome P450 2E1 and its catalytic activity in rat testis. Biochem Biophys Res Commun 246: 578-583.

Jianmongkol S, Marable BR, Berkman CE, Talley TT, Thompson CM, Richardson RJ (1999) Kinetic evidence for different mechanisms of acetylcholinesterase inhibition by (1R)- and (1S)-stereoisomers of isomalathion. Toxicol Appl Pharmacol 155: 43-53.

Marable BR, Lightle R, Richardson RJ, Philbert MA (1998) Potentiation of di-n-butyl-2,2-dichlorovinylphosphate (DBCVP) neurotoxicity by phenylmethanesulfonylfluoride (PMSF) causes degeneration of cerebellar Purkinje cells. Toxicol Sci 42: 125.

Marty MS, Loch-Caruso R (1998) 2-Methoxyethanol inhibits gap junctional communication in rat myometrial myocytes. Cell Biol Toxicol 14: 199-210.

McNutt TL, Harris C (1998) Modulation of intracellular glutathione and cysteine metabolism in bovine oviduct epithelial cells cultured in vitro. Biol Reprod 59: 314-320.

Pitt JA, Carney EW (1999) Development of a gestational age-based morphology evaluation system for in vivo and in vitro rabbit embryos. Teratology 59: 88-101.

Pitt JA, Carney EW (1999) Evaluation of various toxicants in rabbit whole-embryo culture using a new morphologically-based evaluation system. Teratology 59: 102-109.

Pitt JA, Zoellner MJ, Carney EW (1997) Developmental toxicity of dietary zinc deficiency in New Zealand white rabbits. Reprod Toxicol 11: 781-789.

Pitt JA, Zoellner MJ, Carney EW (1997) In vivo and in vitro developmental toxicity in LPS-induced zinc-deficiency in rabbits. Reprod Toxicol 11: 771-779.

Randall JC, Ambroso JL, Groutas WC, Brubaker MJ, Richardson RJ (1997) Inhibition of neurotoxic esterase in vitro by novel carbamates. Toxicol Appl Pharmacol 143: 173-178.

Randall JC, Yano BL, Richardson RJ (1997) Potentiation of organophosphorus compound-induced delayed neurotoxicity (OPIDN) in the central and peripheral nervous system of the adult hen: Distribution of axonal lesions. J Toxicol Environ Health 51: 571-590.

Reed JR, Kraft MD, Hollenberg PF (2000) Rat liver cytosol catalyzes a reaction involving activated N-nitrosodimethylamine and a carbohydrate from the pentose phosphate pathway. Chem Res Toxicol 13:126-133.

Regal K A, Schrag ML, Kent UM, Wienkers LC, Hollenberg PF (2000) Mechanism-based inactivation of P450 2B1 by 7-ethynylcoumarin: Verification of apo-P450 adduction by electrospray ion trap mass spectrometry. Chem Res Toxicol 13:262-270.

Regal K, Nelson S (2000) Orientation of Caffeine Within the Active Site of Human Cytochrome P4501A2 Based on Longitudinal (T1) Relaxation Measurements. Arch Biochem Biophys 384:47-58.

Regal KA, Schrag ML, Kent UM, Wienkers LC, Hollenberg PF (2000) Mechanism-based inactivation of cytochrome P450 2B1 by 7-ethynyl-coumarin: Verification of apo-P450 adduction by electrospray ion trap mass spectrometry. Chem Res Toxicol 13: 262-270.

Taneja N, Tjalkens R, Philbert MA, Rehemtulla A. (2001) Mitochondria as the primary target for ionizing radiation induced apoptosis. Oncogene 20: 167 177.

Tjalkens RB, Ewing MM, Philbert MA (2000) Differential cellular regulation of the mitochondrial permeability transition in an in vitro model of 1,3-dinitrobenzene-induced encephalopathy. Brain Res 874:165-177.

Xu H, Aylott JW, Kopelman R, Miller TJ, Philbert MA (2001) A real-time ratiometric method for the determination of molecular oxygen inside living cells using sol-gel-based spherical optical nanosensors with applications to rat C6 glioma. Anal Chem 73:4124-4133.