Environmental Health Sciences 
Environmental Toxicology Training Grant - Publications
Supported by the National Institute of Environmental Health Sciences, NIH
Recent Trainee Publications
Akella SS, Beck MJ, Philbert MA, Harris C (2000) Comparison of in vitro
and in utero ethanol exposure on indices of oxidative stress. In Vitro
Mol Toxicol 13:281-296.
Akella SS, Harris C (1999) Pyridine nucleotide flux and glutathione
oxidation in the cultured rat conceptus. Reprod Toxicol 13:203-213.
Akella SS, Harris C (2001) Developmental ontogeny of NAD+ kinase in
the rat conceptus. Toxicol Appl Pharmacol 170:124-129.
Ambroso JL, Larsen SJV, Brabec RK, Harris C (1997) Fluorometric analysis
of endocytosis and lysosomal proteolysis in the rat visceral yolk sac
during whole embryo culture. Teratology 56: 201-209.
Beck MJ, McLellan C, Lightle RL, Philbert MA, Harris C (2001) Spatial
glutathione and cysteine distribution and chemical modulation in the
early organogenesis-stage rat conceptus in utero. Toxicol Sci 62:92-102.
Bestervelt LL, Pitt JA, Nolan CJ, Cai Y, Piper DW, Dybowski JA, Dayharsh
GA, Piper WN (1998) In vitro 2,3,7,8-tetrachlorodibenzo-p-dioxin interference
with the anterior pituitary hormone adrenocorticortropin. Toxicol Sci
44:107-115.
Bestervelt LL, Pitt JA, Piper WN (1998) Evidence for Ah receptor mediation
of increased ACTH concentrations in primary cultures of rat anterior
pituitary cells exposed to TCDD. Toxicol Sci 46:294-299.
Billecke SS, Primo-Parmo SL, Dunlop CS, Doorn JA, La Du BN, Broomfield
CA (1999) Characterization of a soluble mouse liver enzyme capable of
hydrolyzing diisopropyl phosphofluoridate. Chem Biol Interact 119-120:
251-256.
Brasuel M, Kopelman R, Miller TJ, Tjalkens R, Philbert MA (2001) Fluorescent
nanosensors for intracellular chemical analysis: decyl methacrylate
liquid polymer matrix and ion-exchange-based potassium PEBBLE sensors
with real-time application to viable rat C6 glioma cells. Anal Chem
73:2221-2228.
Brasuel M, Kopelman R, Miller TJ, Tjalkens R, Philbert MA (2001) Fluorescent
nanosensors for intracellular chemical analysis: decyl methacrylate
liquid polymer matrix and ion exchange based potassium PEBBLE sensors
with real time application to viable rat C6 glioma cells. Anal Chem
73: 2221 2228.
Choe H-S, Hansen JM, Harris C (2001) Spatial and temporal ontogenies
of antioxidant enzyme activities during development of the prenatal
rat. J Biochem Mol Toxicol 15: 197-206.
Clark HA, Tjalkens R, Philbert MA, Kopelman R (1999) Optical nanosensors
for chemical analysis inside single living cells. Part II: Sensors specific
for pH and calcium and the intracellular application of PEBBLE sensors.
Ana Chem 71: 4837 4843.
Criswell KA, Loch-Caruso R (1999) Lindane-induced inhibition of spontaneous
contractions of pregnant rat uterus. Biol Repro 13: 481-490.
Doorn JA, Gage DA, Schall M, Talley TT, Thompson CM, Richardson RJ
(2000) Inhibition of acetylcholinesterase by (1S,3S)-isomalathion proceeds
with loss of thiomethyl: Kinetic and mass spectral evidence for an unexpected
primary leaving group. Chem Res Toxicol 13: 1313-1320.
Doorn JA, Schall M, Gage DA, Talley TT, Thompson CM, Richardson RJ
(2001) Identification of butyrylcholinesterase adducts after inhibition
with isomalathion using mass spectrometry: Difference in mechanism between
(1R) and (1S) stereoisomers. Toxicol Appl Pharmacol 176: 73-80.
Doorn JA, Sorenson RC, Billecke SS, Hsu C, La Du, BN (1999) Evidence
that several conserved histidine residues are required for hydrolytic
activity of human paraoxonase/arylesterase. Chem Biol Interact 119-120:
235-241.
Doorn JA, Talley TT, Thompson CM, Richardson RJ (2001) Probing the
active sites of butyrylcholinesterase and cholesterol esterase with
isomalathion: Conserved stereoselective inactivation of serine hydrolases
structurally related to acetylcholinesterase. Chem Res Toxicol 14: 807-813.
Hanna IH, Reed JR, Guengerich FP, Hollenberg PF (2000) Expression of
human cytochrome P450 2B6 in Escherichia coli: characterization of catalytic
activity and expression levels in human liver. Arch Biochem Biophys
376:206-216.
Hansen JM, Carney EW, Harris C (1999) Differential alteration by thalidomide
of the glutathione content of rat vs. rabbit conceptuses in vitro. Reprod
Toxicol 13: 547-554.
Hansen JM, Carney EW, Harris C (2001) Alterations in differentiation
in the rat and rabbit limb bud micromass culture by glutathione modulating
agents. Free Rad Biol Med 31: 1582-1592.
Hansen JM, Choe H-S, Carney EW, Harris C (2001) Differential antioxidant
enzyme activities and glutathione content between rat and rabbit conceptuses.
Free Radical Biology and Medicine 30: 1078-1088.
Hansen JM, Harris C (2002) Thalidomide alters redox status and selectively
alters glutathione in rabbit vs. rat embryonic limb bud cells. J Pharmacol
Exper Ther 300: 768-776.
Jiang Y, Kuo CL, Pernecky SJ, Coon MJ, Piper WN (1998) Cytochrome P450
2E1 mRNA in the rat prostate: Detection and quantitation by competitive
reverse transcription and polymerase chain reaction. Molec Cell Probes
12: 263-271.
Jiang Y, Kuo CL, Pernecky SJ, Piper WN (1998) The detection of cytochrome
P450 2E1 and its catalytic activity in rat testis. Biochem Biophys Res
Commun 246: 578-583.
Jianmongkol S, Marable BR, Berkman CE, Talley TT, Thompson CM, Richardson
RJ (1999) Kinetic evidence for different mechanisms of acetylcholinesterase
inhibition by (1R)- and (1S)-stereoisomers of isomalathion. Toxicol
Appl Pharmacol 155: 43-53.
Marable BR, Lightle R, Richardson RJ, Philbert MA (1998) Potentiation
of di-n-butyl-2,2-dichlorovinylphosphate (DBCVP) neurotoxicity by phenylmethanesulfonylfluoride
(PMSF) causes degeneration of cerebellar Purkinje cells. Toxicol Sci
42: 125.
Marty MS, Loch-Caruso R (1998) 2-Methoxyethanol inhibits gap junctional
communication in rat myometrial myocytes. Cell Biol Toxicol 14: 199-210.
McNutt TL, Harris C (1998) Modulation of intracellular glutathione
and cysteine metabolism in bovine oviduct epithelial cells cultured
in vitro. Biol Reprod 59: 314-320.
Pitt JA, Carney EW (1999) Development of a gestational age-based morphology
evaluation system for in vivo and in vitro rabbit embryos. Teratology
59: 88-101.
Pitt JA, Carney EW (1999) Evaluation of various toxicants in rabbit
whole-embryo culture using a new morphologically-based evaluation system.
Teratology 59: 102-109.
Pitt JA, Zoellner MJ, Carney EW (1997) Developmental toxicity of dietary
zinc deficiency in New Zealand white rabbits. Reprod Toxicol 11: 781-789.
Pitt JA, Zoellner MJ, Carney EW (1997) In vivo and in vitro developmental
toxicity in LPS-induced zinc-deficiency in rabbits. Reprod Toxicol 11:
771-779.
Randall JC, Ambroso JL, Groutas WC, Brubaker MJ, Richardson RJ (1997)
Inhibition of neurotoxic esterase in vitro by novel carbamates. Toxicol
Appl Pharmacol 143: 173-178.
Randall JC, Yano BL, Richardson RJ (1997) Potentiation of organophosphorus
compound-induced delayed neurotoxicity (OPIDN) in the central and peripheral
nervous system of the adult hen: Distribution of axonal lesions. J Toxicol
Environ Health 51: 571-590.
Reed JR, Kraft MD, Hollenberg PF (2000) Rat liver cytosol catalyzes
a reaction involving activated N-nitrosodimethylamine and a carbohydrate
from the pentose phosphate pathway. Chem Res Toxicol 13:126-133.
Regal K A, Schrag ML, Kent UM, Wienkers LC, Hollenberg PF (2000) Mechanism-based
inactivation of P450 2B1 by 7-ethynylcoumarin: Verification of apo-P450
adduction by electrospray ion trap mass spectrometry. Chem Res Toxicol
13:262-270.
Regal K, Nelson S (2000) Orientation of Caffeine Within the Active
Site of Human Cytochrome P4501A2 Based on Longitudinal (T1) Relaxation
Measurements. Arch Biochem Biophys 384:47-58.
Regal KA, Schrag ML, Kent UM, Wienkers LC, Hollenberg PF (2000) Mechanism-based
inactivation of cytochrome P450 2B1 by 7-ethynyl-coumarin: Verification
of apo-P450 adduction by electrospray ion trap mass spectrometry. Chem
Res Toxicol 13: 262-270.
Taneja N, Tjalkens R, Philbert MA, Rehemtulla A. (2001) Mitochondria
as the primary target for ionizing radiation induced apoptosis. Oncogene
20: 167 177.
Tjalkens RB, Ewing MM, Philbert MA (2000) Differential cellular regulation
of the mitochondrial permeability transition in an in vitro model of
1,3-dinitrobenzene-induced encephalopathy. Brain Res 874:165-177.
Xu H, Aylott JW, Kopelman R, Miller TJ, Philbert MA (2001) A real-time
ratiometric method for the determination of molecular oxygen inside
living cells using sol-gel-based spherical optical nanosensors with
applications to rat C6 glioma. Anal Chem 73:4124-4133.
|
back to top