Professional Summary
Dr. Rudy J. Richardson received his B.S. (magna cum laude) in Chemistry from Wichita State University. Upon achieving Ph.D. candidacy in Chemistry at SUNY Stony Brook, he transferred to Harvard, where he earned the Sc.M. and Sc.D. degrees in Physiology/Toxicology. After postdoctoral work in Neurochemistry at the Medical Research Council Toxicology Unit in Carshalton, England, he joined the University of Michigan as Assistant Professor of Toxicology. Apart from sabbatical leaves at Warner-Lambert/Parke-Davis (now Pfizer) in Ann Arbor and the University of Padua in Italy, Dr. Richardson has been based at Michigan, where he has risen through the ranks to full professor. During 1993-1999 he served as director of the Toxicology Program and in 1998 he was appointed as the Dow Professor of Toxicology. He is board-certified by the American Board of Toxicology (DABT). His research has focused on mechanisms of acute and delayed neurotoxicity of organophosphorus compounds. Currently he uses kinetics, molecular modeling and mass spectrometry to understand interactions of toxicants with target macromolecules and to develop biomarkers of exposure, toxicity and disease.
Courses Taught
EHS506: Principles of Toxicology
EHS624: Mechanisms of Neurotoxicology
EHS628: Toxicology Research Analysis and Presentation
EHS869: Doctoral Seminar in Occupational and Environmental Health
Education
Sc.D., Physiology/Toxicology, Harvard University, 1974
Sc.M., Physiology/Toxicology, Harvard University, 1973
B.S., magna cum laude in Chemistry, Wichita State University, 1967
Research Interest & Projects
Mechanisms of neurological and autoimmune diseases and their modulation by environmental agents, genetics and age. Biomarkers of drug or toxicant exposure, physiological dysfunction and recovery. Interactions of ligands with target macromolecules using kinetics, molecular modeling and mass spectrometry. Stereochemistry and structure-activity relationships of the toxic or therapeutic actions of organophosphorus compounds and other inhibitors of serine hydrolases. Scientific basis of risk assessment and public health policy.
Development of a Medical Analytical System for OPIDN Risk Assessment
Principal Investigator: Richardson, R.
Sponsor: U.S. Civilian Research and Development Foundation
Mechanisms of Aging of Phophylated Serime Hydrolases
Principal Investigator: Richardson, R.
Sponsor: DOD/Army
Environmental Toxicology Pre/Post Doctoral Research Training
Principal Investigator: Richardson, R.
Sponsor: NIH/NIEHS
Selected Publications
Albers, J.W., Berent, S., Garabrant, D.H., Giordani, B., Schwietzer, S.J., Garrison, R.P. and Richardson, R.J. (2004). The effects of occupational exposure to chlorpyrifos on the central nervous system. A prospective cohort study. J Occ Environ Med, 46, 367-378.
Albers, J.W., Garabrant, D.H., Schwietzer, S., Garrison, R.P., Richardson, R.J. and Berent, S. (2004). Absence of sensory neuropathy among workers with occupational exposure to chlorpyrifos. Muscle & Nerve, 29, 677-686.
Kropp, T.J., Glynn, P. and Richardson, R.J. (2004). The mipafox-inhibited catalytic domain of human neuropathy target esterase ages by reversible proton loss. Biochemistry, 43, 3716-3722.
Albers, J.W., Garabrant, D.H., Schweitzer, S.J., Garrison, R.P., Richardson, R.J. and Berent, S. (2004). The effects of occupational exposure to chlorpyrifos on the peripheral nervous system: A prospective cohort study. Occ Environ Med, 61, 201-211.
Doorn, J.A., Thompson, C.M., Christner, R.B. and Richardson, R.J. (2003). Stereoselective inactivation of Torpedo californica acetylcholinesterase by isomalathion: inhibitory reactions with (1R)- and (1S)-isomers proceed by different mechanisms. Chem Res Toxicol, 16, 958-965.
Brott, D.A., Maher, R.J., Parrish, C.R., Richardson, R.J. and Smith, A.K. (2003). Flow cytometric characterization of perfused human bone marrow culture: Identification of the major cell lineages and correlation with the CFU-GM assay. Cytometry, 53A, 22-27.
Malygin, V.V., Sokolov, V.B., Richardson, R.J. and Makaeva, G.F. (2003). Quantitative structure-activity relationships predict the delayed neurotoxicity potential of a series of O-alkyl-O-methylchloroformimino phenylphosphonates. J Toxicol Environ Health, Part A, 66, 611-625.
Makaeva, G.F., Sigolaeva, L.V., Zhuravleva, L.V., Eremenko, A.V., Kurochkin, I.N., Malygin, V.V. and Richardson, R.J. (2003). Biosensor detection of neuropathy target esterase in whole blood as a biomarker of exposure to neuropathic organophosphorus compounds. J Toxicol Environ Health, Part I, 66, 599-610.
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