Professional Summary
ACADEMIC APPOINTMENTS
2002 - Assistant Professor of Human Genetics, University of Michigan
1997 - Assistant Professor of Epidemiology, University of Michigan
1997 - Assistant Professor of Internal Medicine, University of Michigan
CLINICAL/HOSPITAL APPOINTMENTS
1998 - Marquette General Hospital, Consulting Physician
1997 - VA Ann Arbor Healthcare System, Attending Physician
1997 - University of Michigan Health System, Attending Physician
Education
Doctor of Medicine, University of Pennsylvania, 1988-1992
Doctor of Philosophy, Epidemiology, Yale University Graduate School, 1986-1988
M.P.H., Yale University School of Medicine, 1984-1986
B.A., English/Biology, University of Pennsylvania, 1980-1984
POSTDOCTORAL TRAINING Fellow in Clinical Medical Genetics, University of Michigan, 1997-1999 Fellow in Medical Oncology, Johns Hopkins Hospital, 1994-1997 Residency in Internal Medicine, University of Pennsylvania, 1993-1994 Internship in Internal Medicine, University of Pennsylvania, 1992-1993
Research Interest & Projects
Molecular Epidemiology of Colorectal Cancer: The broad objective of this study is to examine how environmental factors may modify genetic risk of colorectal cancer (CRC). The major goals of this study are to measure the risks of developing cancer associated with the APC I1307K allele and identify and measure potential effect modification of genetic and environmental risks in the pathogenesis of CRC.
The Genes, Environment and Melanoma Study: This multidisciplinary, international collaborative study of genetic and environmental contributions to multiple primary melanoma will measure the relative risk for mutations and polymorphisms of cell cycle genes, pigmentary genes, and nucleotide excision repair genes. These will be examined in relation to solar exposure. Dr. Gruber is the PI of the University of Michigan site.
Molecular Markers, Health Behaviors, and Comorbidities as Predictors of Tumor Recurrence, Survival and Quality of Life in Head and Neck Cancer Patients NIH Head and Neck SPORE: This population based study of patients with head and neck cancer is designed to identify prognostic factors and modifiable predictors of tumor recurrence, survival and quality of life.
Susceptibility Prediction in Colorectal Cancer: This collaborative clinical study of familial colon cancer will measure penetrance of colon cancer genes and build statistical models for clinical prediction.
Selected Publications
Jeter, J., Kohlmann, W., Gruber, S.B. (2006). Genetics of Colorectal Cancer. Oncology, 20(3), 269-276.
Gruber, S.B. (2006). New developments in Lynch Syndrome (Hereditary NonPolyposis Colorectal Cancer) and mismatch repair gene testing. Gastroenterology, 130, 577-87.
Rosamilia, L.L., Schwartz, J.L., Lowe, L., Gruber, S.B., Quint, E.H., Johnson, T.M., Reynolds, R.K., and Haefner, H.K. (2006). Vulvar melanoma in a 10-year-old girl in association with lichen sclerosus. Journal of the American Academy of Dematology, 54, S52-3.
Gruber, S.B. (2005). The value of small observations in the era of big science. Cancer Epidemiology Biomarkers & Prevention, 14(11), 2472-3.
Douglas, J.A., Gruber, S.B., Meister, K.A., Bonner, J.D., Watson, P., Krush, A.J., Lynch, H.T. (2005). History and Molecular Genetics of Hereditary Non-Polyposis Colorectal Cancer in Family G-A Century Later. JAMA, 294(17), 2195-202.
Poynter, J.N., Gruber, S.B., Higgins, P.D.R., Almog, R., Bonner, J.D., Rennert, H.S., Low, M., Greenson, J.K., Rennert, G. (2005). Statins and the risk of colorectal cancer. New England Journal of Medicine, 352, 2184-92.
Lipkin, S.M., Rozek, L.S., Rennert, G., Yang, W., Chieh, P., Chen, J., Hacia, J., Hunt, N., Shin, B., Fodor, S., Kokoris, M., Greenson, J.K., Fearon, E.R., Lynch, H.T., Collins, F.S., Gruber, S.B. (2004). The MLH1 D132H variant is associated with susceptibility. Nature Genetics, 39(7), 694-9.
Amend, K.L., Tomsho, L.P., Bonner, J.D., Johnson, T.M., Berwick, M., Elder, J.T., Gruber, S.B. (2004). EGF gene polymorphism and the risk of incident primary melanoma. Cancer Research, 64, 2668-2672.
Niell, B.L., Rennert, G., Bonner, J.D., Almog, R., Tomsho, L.P., Gruber, S.B. (2004). BRCA1 and BRCA2 founder mutations and the risk of colorectal cancer. Journal of the National Cancer Institute, 96(1), 15-21.
Professional Affiliations
American Society of Clinical Investigation
Society for Epidemiologic Research
American Society of Clinical Oncology
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