Prerequisites: Biol Chem 515 or equivalent, EHS 511
The objective of this course is to provide an in-depth analysis of the biochemical and molecular pathways altered in cells and organisms through exposure to environmental and therapeutic chemicals. The content is directed toward the needs of doctoral and masters students in the basic biomedical sciences involved in laboratory research projects. Topics will cover areas of modern research emphasis and focus on how chemicals act to disturb cellular processes through interaction with cellular receptors, ion channels, transporters, signal transduction pathways, transcription factors, metabolic pathways, enzymes, cytoskeletal elements and other macromolecular targets. Specific information about the latest theories on the regulation and initiation of cell death, mediation of toxicity through hredox status and oxidative stress, mechanisms of carcinogenesis, genoxicity and immunotoxicology will also be discussed.
EHS622
Mechanisms of Developmental Toxicology
Fall
term(s)
2 Credit Hour(s)
Instructor(s):
Harris, Craig
Prerequisites: Grad Status, Biochem 515 or equiv
Integration and analysis of scientific information to enhance understanding and elucidate biochemical and molecular mechanisms in developmental toxicology. Course emphasis is on student discussions of the theoretical and practical aspects of embryology as related to biochemical, physiological and molecular mechanisms of embryotoxicity based on readings from the scientific literature.
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