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Michael Boehnke

Michael Boehnke, Ph.D.

Richard G. Cornell Distinguished University Professor of Biostatistics

Director, Center for Statistical Genetics

Director, Genome Science Training Program

M4108 SPH II      Vcard icon
1415 Washington Heights
Ann Arbor, Michigan 48109-2029

Office: (734) 936-1001; Fax: (734) 615-8322

E-mail: boehnke@umich.edu

Website(s): Center for Statistical Genetics; FUSION Study of Type 2 Diabetes; Google Scholar Citations; Publications in PDF Format from 2000

Curriculum Vitae (PDF)

Professional Summary

Michael Boehnke is the Richard G. Cornell Distinguished University Professor of Biostatistics. He is Director of the University of Michigan Center for Statistical Genetics and of the University of Michigan Genome Science Training Program, a member of the Institute of Medicine of the National Academy of Sciences, and a Fellow of the American Statistical Association and of the American Association for the Advancement of Science. Dr. Boehnke did his undergraduate degree in Mathematics at the University of Oregon and his PhD in Biomathematics at UCLA. He has been on the faculty at Michigan since 1984. Dr. Boehnke's research focuses on problems of study design and statistical analysis of human genetic data with a particular emphasis on development and application of statistical methods for human gene mapping. His current statistical methods research focuses on disease and trait association studies based on genome-wide sequencing and genotyping data. He is principal investigator of the Finland-United States Investigation of NIDDM (FUSION) study of the genetics of type 2 diabetes, the GoT2D and T2D-GENES type 2 diabetes sequencing studies, and the BRIDGES study of the genetics of bipolar disorder. He also is founder and steering committee member of the DIAGRAM (type 2 diabetes), MAGIC (glucose and insulin traits), GIANT (anthropometric traits), and Global Lipids genome-wide association meta-analysis consortia. Dr. Boehnke has >240 refereed publication and has chaired or co-chaired 20 doctoral committees and supervised 9 post-doctoral fellows.

Courses Taught

BIOSTAT503: Introduction to Biostatistics    Syllabus (PDF)

Education

Ph.D., Biomathematics, UCLA, 1983
B.A., Mathematics, University of Oregon, 1977

Research Interests & Projects

Design and Analysis of Human Gene Mapping Studies Identifying Genes for Type 2 Diabetes: FUSION Identifying T2D Variants by DNA Sequencing in Multiethnic Samples Whole Genome and Exome Sequencing for Bipolar Disorder

Selected Publications

Search PubMed for publications by Michael Boehnke >>

Ma C, Blackwell T, Boehnke M, and Scott LJ (2013). Recommended joint and meta-analysis strategies for case-control association testing of single low-count variants. Genetic Epidemiology, 37, 539-559.

Huyghe JR, Jackson AU, Fogarty MP, Buchkovich ML, Stan?ákova A, Stringham HM, Sim X, Yang L, Fuchsberger C, Cederberg H, Chines PS, Teslovich TM, Romm JM, Ling H, McMullen I, Ingersoll R, Pugh EW, Doheny KF, Neale BM, Daly MJ, Kuusisto J, Scott LJ, Kang HM, Collins FC, Abecasis GR, Watanabe RM, Boehnke M, Laakso M, and Mohlke K (2013). Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion Nature Genetics, 197-201.

Morris AP, Voight BF, Teslovich TM, Ferreira T, Segrè AV, Steinthorsdottir V, Strawbridge RJ, Khan H, Grallert H, Mahajan A, Prokopenko I, Kang HM, Dina C, Esko T, Fraser RM, Kanoni S, Kumar A, Lagou V, Langenberg C, Luan J, Lindgren CM, Müller-Nurasyid M, Pechlivanis S, Rayner NW, Scott LJ, Wiltshire S, Yengo L, Kinnunen L, Rossin EJ, Raychaudhuri S, Johnson AD, Dimas AS, Loos RJ, Vedantam S, Chen H, Florez JC, Fox C, Liu CT, Rybin D, Couper DJ, Kao WH, Li M, Cornelis MC, Kraft P, Sun Q, van Dam RM, Stringham HM, Chines PS, Fischer K, Fontanillas P, Holmen OL, Hunt SE, Jackson AU, Kong A, Lawrence R, Meyer J, Perry JR, Platou CG, Potter S, Rehnberg E, Robertson N, Sivapalaratnam S, Stan?áková A, Stirrups K, Thorleifsson G, Tikkanen E, Wood AR, Almgren P, Atalay M, Benediktsson R, Bonnycastle LL, Burtt N, Carey J, Charpentier G, Crenshaw AT, Doney AS, Dorkhan M, Edkins S, Emilsson V, Eury E, Forsen T, Gertow K, Gigante B, Grant GB, Groves CJ, Guiducci C, Herder C, Hreidarsson AB, Hui J, James A, Jonsson A, Rathmann W, Klopp N, Kravic J, Krjutškov K, Langford C, Leander K, Lindholm E, Lobbens S, Männistö S, Mirza G, Mühleisen TW, Musk B, Parkin M, Rallidis L, Saramies J, Sennblad B, Shah S, Sigurðsson G, Silveira A, Steinbach G, Thorand B, Trakalo J, Veglia F, Wennauer R, Winckler W, Zabaneh D, Campbell H, van Duijn C, Uitterlinden AG, Hofman A, Sijbrands E, Abecasis GR, Owen KR, Zeggini E, Trip MD, Forouhi NG, Syvänen AC, Eriksson JG, Peltonen L, Nöthen MM, Balkau B, Palmer CN, Lyssenko V, Tuomi T, Isomaa B, Hunter DJ, Qi L; Wellcome Trust Case Control Consortium; Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC) Investigators; Genetic Investigation of ANthropometric Traits (GIANT) Consortium; Asian Genetic Epidemiology Network-Type 2 Diabetes (AGEN-T2D) Consortium; South Asian Type 2 Diabetes (SAT2D) Consortium, Shuldiner AR, Roden M, Barroso I, Wilsgaard T, Beilby J, Hovingh K, Price JF, Wilson JF, Rauramaa R, Lakka TA, Lind L, Dedoussis G, Njølstad I, Pedersen NL, Khaw KT, Wareham NJ, Keinanen-Kiukaanniemi SM, Saaristo TE, Korpi-Hyövälti E, Saltevo J, Laakso M, Kuusisto J, Metspalu A, Collins FS, Mohlke KL, Bergman RN, Tuomilehto J, Boehm BO, Gieger C, Hveem K, Cauchi S, Froguel P, Baldassarre D, Tremoli E, Humphries SE, Saleheen D, Danesh J, Ingelsson E, Ripatti S, Salomaa V, Erbel R, Jöckel KH, Moebus S, Peters A, Illig T, de Faire U, Hamsten A, Morris AD, Donnelly PJ, Frayling TM, Hattersley AT, Boerwinkle E, Melander O, Kathiresan S, Nilsson PM, Deloukas P, Thorsteinsdottir U, Groop LC, Stefansson K, Hu F, Pankow JS, Dupuis J, Meigs JB, Altshuler D, Boehnke M, McCarthy MI, and DIAGRAM Consortium (2012). Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes Nature Genetics, 981-990.

Jun G, Flickinger M, Hetrick KN, Romm JM, Doheny KF, Abecasis GR, Boehnke M, and Kang HM (2012). Detecting and estimating contamination of human DNA samples in sequencing and array-based genotype data American Journal of Human Genetics, 839-848.

Teslovich TM, Musunuru K, Smith AV, Edmondson AC, Stylianou IM, ..., Schunkert H, Cupples LA, Sandhu MS, Ridker PM, Rader DJ, van Duijn CM, Peltonen L, Abecasis GR, Boehnke M, and Kathiresan S (2010). Biological, clinical, and population relevance of 95 loci mapped for serum lipid concentrations Nature

Scott LJ, Muglia P, Kong XQ, Guan W, Flickinger M, Upmanyu R, Tozzi F, Li JZ, Burmeister M, Absher D, Thompson RC, Francks C, Meng F, Antoniades A, Southwick AM, Schatzberg AF, Bunney WE, Barchas JD, Jones EG, Day R, Matthews K, McGuffin P, Strauss JS, Kennedy JL, Middleton L, Roses AD, Watson SJ, Vincent JB, Myers RM, Farmer AE, Akil H, Burns DK, and Boehnke M (2009). Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry. Proceedings of the National Academy of Sciences USA, 106, 7501-7506.

Xiao R and Boehnke M (2009). Quantifying and correcting for the winner's curse in genetic association studies. Genetic Epidemiology, 33, 453-462.

Scott LJ, Mohlke KL, Bonnycastle LL, Willer CJ, Li Y, Duren WL, Erdos MR, Stringham HM, Chines PS, Jackson AU, Prokunina-Olsson L, Ding CJ, Swift AJ, Narisu N, Hu T, Pruim R, Xiao R, Li X-Y, Conneely KN, Riebow NL, Sprau AG, Tong M, White PP, Hetrick KN, Barnhart MW, Bark CW, Goldstein JL, Watkins L, Xiang F, Saramies J, Buchanan TA, Watanabe RM, Valle TT, Kinnunen L, Abecasis GR, Pugh EW, Doheny KF, Bergman RN, Tuomilehto J, Collins FS, and Boehnke M (2007). A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science, 316, 1341-1345.

Professional Affiliations

American Society for Human Genetics
International Genetic Epidemiology Society