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Chuanwu Xi

Chuanwu Xi, Ph.D.

Associate Professor, Environmental Health Sciences

6626 SPH Tower      Vcard icon
1415 Washington Heights
Ann Arbor, Michigan 48109-2029

Office: (734) 615-7594; Fax: (734) 936-7283

E-mail: cxi@umich.edu

Website(s): Xi Lab

Curriculum Vitae (PDF)

Professional Summary

Dr. Xi is a molecular microbiologist and microbial ecologist. His research focuses on biofilms, water quality and treatment and human health in three major inter-related areas: (A) molecular mechanisms of biofilm development; (B) characterization of biofilms and microbial community in industrial and clinical settings and its impact on human health; and (C) development of novel approaches for biofilm control. Prior to joining the faculty of the University of Michigan in 2005, he spent four years at the University of Illinois at Urbana-Champaign and received his Ph.D. from Katholieke Universiteit Leuven, Belgium in 2000.

Courses Taught

EHS570: Water Quality Management
EHS576: Microbiology in Environmental Health
EHS614: Water and Global Health
EHS615: Water Quality and Human Health in the Great Lakes Basin
EHS690: Practice in Global Environmental Health


Ph.D., Applied Biological Sciences, Katholieke Universiteit Leuven, Belgium, 2000
M.Sc., Molecular Microbiology, Guangxi University, China, 1996
B.Sc., Biology, Anhui Normal University, China, 1993

Research Interests & Projects

> > Xi Lab - Biofilms, Water Quality, and Human Health (Leader)

Research in the Xi Lab mainly focuses on biofilms, water quality, and human health. We use molecular and genomic tools to understand molecular mechanisms of persistence and resistance of pathogens in natural, engineered and industrial environments; transmission routes of pathogens from environments to hosts; and their impacts on health of general public and industrial workers. We are particularly interested in the role of biofilms in these processes. In addition, we use advanced imaging tools, high throughput screening techniques, and nanotechnology ... More >>

Biofilms, Water Quality, and Human Health 

> > Microbial Characterization of Metal Removal Fluids and Associated Biofilms Using Molecular Approaches (Principal Investigator)

Characterization of microbial ecology in metal removal fluids and associated biofilms to determine the role of biofilms in MRF-related hypersensitive pneumonitis among workers in automobile plants.... More >>

Microbial Characterization of Metal Removal Fluids and Associated Biofilms Using Molecular Approaches 

> > High throughput screening for chemical compounds inhibiting biofilm formation and growth (Principal Investigator)

The major goal is to screen libraries of small chemical compounds for compounds that inhibit biofilm formation and growth.... More >>

High throughput screening for chemical compounds inhibiting biofilm formation and growth 

> > Spread of antibiotic resistance in the environment and in humans (Co-Principal Investigator)

Antibiotic resistance is known to spread through person-to-person contact, but an environmental route of transmission may also be important in the current surge in antibiotic resistant infections. By mathematically modeling a person-environment-person pathway, we will provide insight into how antibiotic resistance emerges and is transported through the environment.... More >>

Spread of antibiotic resistance in the environment and in humans 

Selected Publications

Search PubMed for publications by Chuanwu Xi >>

Cai W, Wu J, Xi C, Meyerhoff ME. (2012). Diazeniumdiolate-doped poly(lactic-co-glycolic acid)-based nitric oxide releasing films as antibiofilm coatings. Biomaterials

Pinto AJ, Xi C, Raskin L. (2012). Bacterial Community Structure in the Drinking Water Microbiome Is Governed by Filtration Processes. Environ. Sci. Tech.

Song L, Wu J, Xi C. (2012). Biofilms on environmental surfaces: Evaluation of the disinfection efficacy of a novel steam vapor system. Am J Infect Control.

Dai D, Holder D, Raskin L, Xi C. (2011). Separation of the bacterial species, Escherichia coli, from mixed-species microbial communities for transcriptome analysis. BMC Microbiology

Xi, C. and J. Wu (2010). dATP/ATP, a multifunctional nucleotide, stimulates bacterial cell lysis, extracellular DNA release and biofilm development PLoS ONE, 5(10), e13355.

Berry D, Holder D, Xi C, Raskin L. (2010). Comparative transcriptomics of the response of Escherichia coli to the disinfectant monochloramine and to growth conditions inducing monochloramine resistance Water Research, 44(17), 4924-31.

Hodges, A.P., D. Dai, Z. Xiang, P. Woolf, C. Xi, Y. He (2010). Bayesian network expansion identifies new ROS and biofilm regulators PLoS ONE, 5(3), e9513. doi:10.1371/journal.pone.0009513.

Xi, C., Y. Zhang, W. Ye, C. Marrs, C. Simon, B. Foxman, and J. Niragu (2009). Prevalence of Antibiotic Resistance in Drinking Water Treatment and Distribution Systems Applied and Environmental Microbiology, 75, 5714-5718.

Wu, J. and C. Xi (2009). Evaluation of Different Methods for Extracting Extracellular DNA in Biofilm Matrix Applied and Environmental Microbiology, 75(16), 5390-5.

Zhang, Y., C.F. Marrs, C. Simon, C. Xi (2009). Wastewater treatment contributes to selective increase of antibiotic resistance among Acinetobacter spp. Science of the Total Envrionment, 407(12), 3702-3706.

Professional Affiliations

American Society for Microbiology
American Water Works Association
International Water Association
Association of Environmental Engineering and Science Professsors (AEESP)
International Society of Microbial Ecology