EHS601: Foundations in Environmental Health Sciences
EHS660: Environmental Epigenetics and Public Health
EHS801: Research and Communication in the Environmental Health Sciences
Ph.D., Genetics and Genomics & Integrated Toxicology and Environmental Health, Duke University, 2007
M.Sc., Environmental Health and Risk Management, Harvard University, 2003
B.A., Environmental Sciences and Policy & Spanish, Duke University, 1998
Research Interests & Projects
It is increasingly recognized that environmental exposure to chemical, nutritional, and behavioral factors alters gene expression and affects health and disease by not only mutating promoter and coding regions of genes, but also by modifying the epigenome — modifications to DNA that confer an additional layer of heritable gene regulation that lead to disease when deregulated. The Dolinoy Lab investigates environmental epigenetics and gene-environment interactions using animal models, human clinical samples, and human population studies. Specifically, research focuses on ... More >>
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Weinhouse C., Anderson O.S., Jones T.R., Kim J., Liberman S.A., Nahar M.S., Rozek L.S., Jirtle R. L., Dolinoy D.C. (2011). An expression microarray approach for the identification of metastable epialleles in the mouse genome Epigenetics, 6(9)
Faulk C., Dolinoy D.C. (2011). Timing is everything: The when and how of environmentally induced changes in the epigenome of animals. Epigenetics, 6(7), 791-797.
Sartor M.A., Dolinoy D.C., Jones T.R., Colacino J.A., Prince M.E., Carey T.E., Rozek L.S. (2011). Genome-wide methylation and expression differences in HPV(+) and HPV(-) squamous cell carcinoma cell lines are consistent with divergent mechanisms of carcinogenesis. Epigenetics, 6(6), 777-787.
Colacino J.A., Soliman A.S., Calafat A.M., Nahar M.S., Van Zomeren-Dohm A., Hablas A., Seifeldin I.A., Rozek L.S., Dolinoy D.C. (2011). Exposure to phthalates among premenstrual girls from rural and urban Gharbiah, Egypt: A pilot exposure assessment study. Environmental Health, 40
Dolinoy D.C., Weinhouse, C., Jones, T.R., Rozek, L.S., Jirtle, R.L. (2010). Variable histone modifications at the A(vy) metastable epiallele. Epigenetics, 5(7), 1-8.
Dolinoy, D.C. and Jirtle, R.L. (2008). Environmental epigenomics in human health and disease. Environmental and Molecular Mutagenesis, 49(1), 4-8.
Dolinoy DC (2008). The agouti mouse model: an epigenetic biosensor for nutritional and environmental alterations on the fetal epigenome Nutrition Reviews, Suppl 1, 7-11.
Dolinoy D.C., Weidman J.R., Jirtle R.L. (2007). Epigenetic gene regulation: linking early developmental environment to adult disease. Reprod Toxicol, 23(3), 297-307.
Dolinoy, D.C., Huang, D and Jirtle, R.L. (2007). Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development. Proceedings of the National Academy of Sciences, 104, 13056-13061.
Dolinoy D.C., Weidman J.R., Waterland R.A., and Jirtle R.L. (2006). Maternal genistein alters coat color and protects Avy mouse offspring from obesity by modifying the fetal epigenome. Environ Health Perspect., 114(4), 567-572.
2005 - Present: Member, Society of Toxicology
2006 - Present: Member/Chair Epigenetics Special Interest Group, Environmental Mutagen Society
2008 - Present: Member, Michigan Metabolomics and Obesity Center (MMOC)
2009 - Present: Member, UM Comprehensive Cancer Center
2011 - Present: Member, American Society for Nutrtion (ASN)
2011 - Present: Vice Chair, Gordon Research Conference on Cellular and Molecular Mechanisms of Toxicity