Dr. Dana Dolinoy serves as the John G. Searle Assistant Professor of Environmental Health Sciences at the University of Michigan School of Public Health (UM SPH) and leads the Environmental Epigenetics and Nutrition Laboratory at UM SPH, which investigates how nutritional and environmental factors interact with epigenetic gene regulation to shape health and disease. Dr. Dolinoy holds a BA in environmental sciences and policy and Spanish from Duke University, an MSc in environmental sciences and engineering from the Harvard School of Public Health, and a PhD in Genetics and Genomics and Integrated Toxicology from Duke University. She serves on the Editorial Board for the Journal of Nutritional Biochemistry as well as Epigenetics, Environmental and Molecular Mutagenesis, and Toxicological Sciences, and is an active member of the Society of Toxicology (SOT), the Environmental Mutagen and Genomics Society (EMGS), and the American Society for Nutrition (ASN), and will serve as Chair of the 2015 Gordon Research Conference (GRC) in Molecular & Cellular Mechanisms of Toxicity. In 2011, Dr. Dolinoy received the Norman Kretchmer Memorial Award from ASN and the Classic Paper of the Year Award from Environmental Health Perspectives for Dolinoy et al. “Maternal genistein alters coat color and protects Avy mouse offspring from obesity by modifying the fetal epigenome.” In 2012, she was the recipient of the Association of Schools of Public Health (ASPH)/Pfizer Research Award for the article, “An Expression Microarray Approach for the Identification of Metastable Epialleles in the Mouse Genome.” This work was cited as a model approach that may allow for directly assessing the role of early environmental exposures in human adult disease.
EHS601: Foundations in Environmental Health Sciences
EHS660: Environmental Epigenetics and Public Health
EHS801: Research and Communication in the Environmental Health Sciences
Ph.D., Genetics and Genomics & Integrated Toxicology and Environmental Health, Duke University, 2007
M.Sc., Environmental Health and Risk Management, Harvard University, 2003
B.A., Environmental Sciences and Policy & Spanish, Duke University, 1998
Research Interests & Projects
It is increasingly recognized that environmental exposure to chemical, nutritional, and behavioral factors alters gene expression and affects health and disease by not only mutating promoter and coding regions of genes, but also by modifying the epigenome — modifications to DNA that confer an additional layer of heritable gene regulation that lead to disease when deregulated. The Dolinoy Lab investigates environmental epigenetics and gene-environment interactions using animal models, human clinical samples, and human population studies. Specifically, research focuses on ... More >>
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Goodrich J.M., Basu N., Franzblau A., Dolinoy D.C. (April, 2013). Mercury biomarker levels and gene specific methylation in the Michigan Dental Association Cohort Environmental and Molecular Mutagenesis
Nahar MS, Liao C, Kannan K, Dolinoy DC (February, 2013). Fetal Liver Bisphenol A Concentrations and Biotransformation Gene Expression Reveal Variable Exposure and Altered Capacity for Metabolism in Humans Journal of Biochemical and Molecular Toxicology
Anderson OS, Peterson KE, Sanchez BN, Zhang Z, Mancuso P, Dolinoy DC FASEB J. 2013 Jan 23. (January, 2013). Perinatal bisphenol A exposure promotes hyperactivity, lean body composition, and hormonal responses across the murine life course The FASEB Journal
Faulk C, Barks A, Dolinoy DC (January, 2013). Phylogenetic and DNA methylation analysis reveal novel regions of variable methylation in the mouse IAP class of transposons BMC Genomics
Weinhouse C., Anderson O.S., Jones T.R., Kim J., Liberman S.A., Nahar M.S., Rozek L.S., Jirtle R. L., Dolinoy D.C. (2011). An expression microarray approach for the identification of metastable epialleles in the mouse genome Epigenetics, 6(9)
Faulk C., Dolinoy D.C. (2011). Timing is everything: The when and how of environmentally induced changes in the epigenome of animals. Epigenetics, 6(7), 791-797.
Sartor M.A., Dolinoy D.C., Jones T.R., Colacino J.A., Prince M.E., Carey T.E., Rozek L.S. (2011). Genome-wide methylation and expression differences in HPV(+) and HPV(-) squamous cell carcinoma cell lines are consistent with divergent mechanisms of carcinogenesis. Epigenetics, 6(6), 777-787.
Colacino J.A., Soliman A.S., Calafat A.M., Nahar M.S., Van Zomeren-Dohm A., Hablas A., Seifeldin I.A., Rozek L.S., Dolinoy D.C. (2011). Exposure to phthalates among premenstrual girls from rural and urban Gharbiah, Egypt: A pilot exposure assessment study. Environmental Health, 40
Dolinoy D.C., Weinhouse, C., Jones, T.R., Rozek, L.S., Jirtle, R.L. (2010). Variable histone modifications at the A(vy) metastable epiallele. Epigenetics, 5(7), 1-8.
Dolinoy, D.C. and Jirtle, R.L. (2008). Environmental epigenomics in human health and disease. Environmental and Molecular Mutagenesis, 49(1), 4-8.
2005 - Present: Member, Society of Toxicology
2006 - Present: Member/Chair Epigenetics Special Interest Group, Environmental Mutagen Society
2008 - Present: Member, Michigan Metabolomics and Obesity Center (MMOC)
2009 - Present: Member, UM Comprehensive Cancer Center
2011 - Present: Member, American Society for Nutrtion (ASN)
2013 - 2015: Chair, 2015 Gordon Research Conference on Cellular and Molecular Mechanisms of Toxicity