Professional Summary
2007-present, Research Assistant Professor, Department of Epidemiology, University of Michigan School of Public Health
1999-2007, Assistant Research Scientist, Department of Epidemiology, University of Michigan School of Public Health.
2000-2001, Lecture, Department of Epidemiology, University of Michigan School of Public Health.
1988 - 1990, Assistant Engineer, Lishui Environmental Science Research Institute, China.
Dr. Zhang is also a member at the Center for Molecular and Clinical Epidemiology of Infectious Diseases and Center for Computational Medicine and Biology, University of Michigan.
Education
Ph.D., Epidemiology, University of Michigan, 1999
M.S., Molecular and Cellular Biology, Eastern Michigan University, 1993
B.E., Biochemical Engineering, Zhejiang Institute of Technology, 1988
Research Interest & Projects
Dr. Zhang's research interests are infectious disease epidemiology, antibiotic resistance, bacterial genomics and pathogenesis, novel molecular techniques for epidemiological study. His long-term goal is to integrate molecular and population levels analyses to understand the emergence, spread and control of infectious diseases. Dr. Zhang has developed new microarray techniques to evaluate the genetic diversity of pathogenic bacterial species and implications of such diversity in disease epidemiology. He is working on various bacterial pathogens including Escherichia coli, Group B Streptococcus, Mycobacterium tuberculosis, Streptococcus mutans, and Haemophilus influenzae. Genomic and bioinformatics approaches are routinely used in his research.
Selected Publications
Zhang, L., Reddi, U., Srinivasan, U., Li, S., Borchardt, S.M., Pillai, P., Mehta, P., Styka, A.N., DeBusscher, J., Marrs, C.F., Foxman, B. (2008). Combining microarray technology and molecular epidemiology to identify genes associated with invasive group B Streptococcus. Interdisciplinary Perspectives on Infectious Diseases, Volume 2008, Article ID 314762, 10 pages. doi:10.1155/2008/314762
Srinivasan, U., Zhang, L., France, A.M., Ghosh, D., Shalaby, W., Xie, J., Marrs, C.F., Foxman, B. (2007). Probe hybridization array typing: a ginary typing method of Escherichia coli. Journal of Clinical Microbiology, 45, 206-14.
Kong, Y., Cave, M.D., Zhang, L., Foxman, B., Marrs, C.F., Bates, J.H., Yang, Z.H. (2006). Population-based study of deletions in five different genomic regions of Mycobacterium tuberculosis and possible clinical relevance of the deletions. Journal of Clinical Microbiology, 44, 3940-6.
Zhang, L., Foxman, B., Gilsdorf, J.R., Marrs, C.F. (2005). Bacterial genomic DNA isolation for microarray analysis using sonication. BioTechniques, 39, 640-644.
Foxman, B., Zhang, L., Koopman, J.S., Manning, S.D., Marrs, C.F. (2005). Choosing an appropriate bacterial typing technique for epidemiologic studies Epidemiol Perspect Innov, 25, 2:10.
Zhang, L., Srinivasan, U., Marrs, C.F., Ghosh, D., Gilsdorf, J.R., Foxman, B. (2004). Library on a slide for bacterial comparative genomics. BMC Microbiology, 4:12
Gu, K., Zhang, L., Jin, T., Rutherford, B. (2004). Exploration of the coordinate expression of genes with Runx2/Cbfa1 during osteoblastic differentiation of C2C12 cells treated by bone morphogenetic protein (BMP)-7. Cells Tissues Organs, 176, 28-40.
Zhang, L., Foxman, B., Marrs, C. (2002). Both urinary and rectal Escherichia coli isolates are dominated by strains of phylogenetic group B2. Journal of Clinical Microbiology, 40, 3951-3955.
Zhang, L., Foxman, B., Manning, S., Tallman, P., Marrs, C.F. (2000). Molecular epidemiologic approaches to UTI gene discovery in uropathogenic Escherichia coli. Infect. Immun., 68, 2009-2015.
Foxman, B., Gillespie, B., Koopman, J., Zhang, L., Palin, K., Tallman, P., Marsh, J.V., Spear, S., Sobel, J.D., Marty, M.J., Marrs, C.F. (2000). Risk factors for second urinary tract infection among college women. American Journal of Epidemiology, 151, 1194-1205.
Professional Affiliations
American Public Health Association
American Society for Microbiology
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