Martin Philbert, Ph.D.

Professor, Environmental Health Sciences

Senior Associate Dean, School of Public Health

1835 SPH I
1415 Washington Heights
Ann Arbor, Michigan 48109-2029

Office: (734) 763-4523; Fax: (734) 763-7105

E-mail: philbert@umich.edu

Courses Taught

EHS513: Pathologic Basis of Disease
EHS616: Introduction to Toxicological Pathology
EHS717: Toxicological Pathology Laboratory

Education

Ph.D., Neurochemistry/Experimental Neurpathology, London University, 1987
B.Sc. (Hons.), Biology/Chemistry, CCAT, Cambridge, 1984

Research Interest & Projects

Active research activities include experimental neuropathology, nitrocompound-induced encephalopathies, mitochondrial mechanisms in non-neuronal cell death, development of Nano-Optical Chemical Systems for in vivo physiology, and nanostructure-based imaging and treatment of tumors of malignant gliomas.

Magnetically Responsive Optical Nanoprobes (MagRONs) & Systems
Principal Investigator: Kopelman, R., Philbert, M.A.
Sponsor: DOD

Cancer Diagnosis & Therapy with Dynamic Nanoplatforms
Principal Investigator: Kopelman, R., Philbert, M.A.
Sponsor: NCI

Nanoscale Modeling & Sensing on Intracellular Transport
Principal Investigator: Philbert, M.A., Sastry, A.M.
Sponsor: Keck Foundation

Role of Astrocyte Mitochondria in Neurotoxicity
Principal Investigator: Philbert, M.A.
Sponsor: NIH

Selected Publications

Moser, V.C., Aschner, M., Richardson, R.J., and Philbert, M.A. (2007). Toxic responses of the nervous system In C. Klaassen (Ed.) Casarett and Doull's Toxicology: The Basic Science of Poisons, 7th edition McGraw-Hill, New York.

Gao, D. Xu, H. Philbert, M.A. and Kopelman, R. (2007). Ultrafine hydrogel nanoparticles: synthetic approach and therapeutic application in living cells Angewandte Chemie-International Edition, 13, 2224-7.

Miller, T.J., Schneider, R.J., Miller, J.A., Martin, B.P., Al-Ubaidi, M.R., Agarwal, N., Dethloff, L.A., Philbert, M.A. (2006). Photoreceptor cell apoptosis induced by the 2-nitroimidazole radiosensitizer, CI-1010, is mediated by p53-linked activation of caspase-3. NeuroToxicology, 1, 44-59.

Buck, S.M., Xu, H., Brasuel, M., Philbert, M.A. and Kopelman, R. (2004). Nanoscale probes encapsulated by biologically localized embedding (PEBBLEs) for ion sensing and imaging in live cells. Talanta, In Press.

Leyton, B.E., Sastry, A.M., Wang, H., Sullivan, K.A., Feldman, E.L., Komorowski, T.E. and Philbert, M.A. (2004). Changes in sciatic nerve collagen morphology and distribution in BB rat diabetic neuropathy. J Biomechanics, In Press.

Koo, Y-E.L., Cao, Y., Kopelman, R., Koo, S.M., Brausuel, M. and Philbert, M.A. (2004). Real-time measurements of dissolved oxygen inside live cells by organically modified silicates fluroescent nanosensors. Anal Chem, 76, 2498-2505.

Park, E., Kopelman, R., Brasuel, M. and Philbert, M.A. (2003). Ratiometric optical PEBBLE nanosensors for magnesium ions in viable cells. Anal Chem, 75, 3784-3791.

Professional Affiliations

2008 - Member and Acting Chair, National Research Council Committee for Review of The Federal Strategy to Address Environmental, Health, and Safety Research Needs for Engineered Nanoscale Materials
2007 - Present, Member, Food and Nutrition Board, Institute of Medicine
2007 - Present, Roundtable on Environmental Health Sciences, Research, and Medicine, Institute of Medicine