Professional Summary
Maureen A. Sartor is a Research Assistant Professor of Biostatistics and at the Center for Computational Medicine and Bioinformatics. She received her Ph.D. in Biostatistics in 2007 from the University of Cincinnati. Her research interests are in developing statistical and bioinformatics methods for high throughput genomic, epigenomic, and proteomic experiments and other bioinformatic applications. Previously, her research has focused on the analysis of microarray data. Her current work involves developing methods for ChIP-Seq data to better assess the biological functionality of results, and methods for integration with other data types. Her lab also develops methods and tools for functional or gene set enrichment testing and is involved in the development of concept mapping software.
Courses Taught
BIOSTAT646: High Throughput Molecular Genetic and Epigenetic Data Analysis
Syllabus (PDF)
BIOINF527: Lectures on the analysis and interpretation of microarray data BIOINF575: Section on programming in R
Education
Ph.D., Biostatistics, University of Cincinnati, 2007
M.S., Biomathematics, North Carolina State University, 2000
B.S., Mathematics, minors in Biology and Computer science, Xavier University, 1998
Research Interests & Projects
My main research interests involve empirical and hierarchical Bayesian models, as well as other statistical modeling, applied to the analysis of high-thoughput genomic data, and understanding and assessing the biological significance of results and molecular pathways involved. With the advent of tiling arrays and next-generation sequencing, new biases and issues surround the question of biological significance and functionality. A current project involves understanding the role of transcription factor ATF4 under ER stress.
Selected Publications
Search PubMed for publications by Maureen Sartor >>
Sartor MA, Mahavisno V, Keshamouni VG, Cavalcoli J, Wright Z, Karnovsky A, Kuick R, Jagadish HV, Mirel B, Weymouth T, Athey B, Omenn GS. (2010). ConceptGen: a gene set enrichment and gene set relation mapping tool. Bioinformatics, 26, 456-463.
Sartor MA, Schnekenburger M, Marlowe JL, Reichard JF, Wang Y, Fan Y, Ma C, Karyala S, Halbleib D, Liu X, Medvedovic M, Puga A (2009). Genome-wide analysis of aryl hydrocarbon receptor binding targets reveals an extensive array of gene clusters that control morphogenetic and developmental programs Env Health Persp, 117(7), 1139-46.
Wang XS, Prensner JR, Chen G, Cao Q, Han B, Dhanasekaran SM, Ponnala R, Cao X, Varambally S, Thomas DG, Giordano TJ, Beer DG, Palanisamy N, Sartor MA, Omenn GS, Chinnaiyan AM. (2009). An integrative approach to reveal driver gene fusions from paired-end sequencing data in cancer Nat Biotechnol, PMID: 19881495
Marshall, M.A., Medvedovic, M., Aronow, B.J. (2011). In vitro multipotent differentiation and barrier function of a human mammary epithelium Epigenetics, 6(6), 777-87.
Sartor, M.A., Leikauf, G.D., Medvedovic, M. (2008). LRpath: A logistic regression approach for identifying enriched biological groups in gene expression data. Bioinformatics
Bakshi, S., Zhang, X., Godoy-Tundidor, S., Cheng, R.Y., Sartor, M.A., Medvedovic, M., Ho, S.M. (2008). Transcriptome analyses in normal prostate epithelial cells exposed to low-dose cadmium: oncogenic and immunomodulations involving the action of tumor necrosis factor Environmental Health Perspectives, 116(6), 769-76.
Tam, N.N., Szeto, C.Y., Sartor, M.A., Medvedovic, M., Ho, S.M. (2008). Gene expression profiling identifies lobe-specific and common disruptions of multiple gene networks in testosterone-supported, 17beta-estradiol- or diethylstilbestorl-induced prostate dysplasia in Noble rats NeoPlasia, 10(1), 20-40.
Hess-Wilson, J.K., Webb, S.L., Daly, H.K., Leung, Y., Bolidson, J., Comstock, C.E.S., Sartor, M.A., Ho, S., Knudsen, K.E. (2007). Unique bisphenol A transcriptome in prostate cancer: novel effects on ERbeta expression that correspond to androgen receptor mutation status. Environmental Health Perspectives, 115(11), 1646-1653.
Ganguly, K., Stoeger, T., Wesselkamper, S.C., Reinhard, C., Sartor, M.A., Medvedovic, M., Tomlinson, C.R., Bolle, I., Mason, J.M., Leikauf, G.D., Schulz, H. (2007). Candidate genes controlling pulmonary function: transcript profiling and predicted protein structure Physiological Genomics, 31(3), 410-421.
Chang, X., Fan, Y., Karyala, S., Schwemberger, S., Tomlinson, C.R., Sartor, M.A., Puga, A." (2007). Ligand-Independent Regulation of Transforming Growth Factor {beta}1 Expression and Cell Cycle Progression by the Aryl Hydrocarbon Receptor Molecular and Cellular Biology, 27(17), 6127-6139.
Professional Affiliations
2009 - Present: Member, ISCB
2011 - Present: Member, AACR
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