Professional Summary
2006 - present, Associate Professor, Department of Epidemiology, School of Public Health, University of Michigan
2000 - 2006, Assistant Professor, Department of Epidemiology, School of Public Health, University of Michigan.
2000, Research Assistant Professor, Division of Infectious Disease, Department of Internal Medicine, College of Medicine, University of Arkansas for Medical Sciences.
1995 - 2000, Postdoctoral Research Associate, Department of Pathology, College of Medicine, University of Arkansas for Medical Sciences.
1984 - 1991, Associate director of Bacterial Vaccine Department, Chengdu Institute of Biological Products, Ministry of Public Health, China.
1982, Research Associate, Department of Quality Control, Chengdu Institute of Biological Products, Ministry of Public Health, China
Courses Taught
EPID399: Independent Research for Undergraduates
EPID609: Vaccines in Public Health
EPID680: Hospital Epidemiology
EPID816: Tuberculosis: Pathogen, Host and Environment
EPID680: Hospital Epidemiology
Education
M.D., North Sichuan College of Medicine, China, 1982
Ph.D., Molecular Epidemiology of Infectious Diseases, Copenhagen University, Denmark, 1995
Fellowship, Vaccine Development, State Serum Institute, Denmark, 1982-84
Fellowship, Molecular Genetics of Microorganisms, University of Lausanne, Switzerland, 1991
Research Interest & Projects
Multidisciplinary approach for identifying microbial, host, environmental, and societal determinants for tuberculosis infection, transmission, and clinical presentation.
Integration of comparative genomics with bioinformatics to study the biology of M. tuberculosis latency.
Genetic mechanisms and rapid diagnosis of drug resistance of M. tuberculosis.
Genetic variations among M. tuberculosis clinical strains and their clinical and epidemiological implications and potential impact on vaccination.
Molecular epidemiology of tuberculosis: development, validation, and application of M. tuberculosis genotyping.
Selected Publications
Hebert, A., Talarico, S., Yang, D., Marrs, C.F., Zhang, L.X., Foxman, B., Yang, Z.H. (December, 2007). NA Polymorphisms of Mycobacterium tuberculosis pepA and PPE18 Genes among Clinical Strains: Implications for Vaccine Efficacy. Infection and Immunity, 75(12), 5798-805.
Talarico, S., Cave, M.D., Foxman, B., Marrs, C.F., Zhang, L., Bates, J.H., Yang, Z. (July, 2007). Association of Mycobacterium tuberculosis PE_PGRS33 Polymorphism with clinical and epidemiological characteristics. Tuberculosis, 87(4), 338-46.
France, A.F., Cave, M.D., Bates, J., Yang, Z.H. (September, 2007). What's driving the decline of incidence of tuberculosis in Arkansas? A molecular epidemiologic analysis of tuberculosis rends in a rural, low-incidence population. American Journal of Epidemiology, 166(6), 622-71.
Kong, Y., Cave, M.D., Zhang, L., Foxman, B., Marrs, C.F., Bates, J.H., Yang, Z.H. (February, 2007). Association between Mycobacterium tuberculosis Beijing/W lineage strain infection and extrathoracic tuberculosis: Insights from epidemiologic and clinical characterization of the three principal genetic groups of M. tuberculosis clinical isolates. Journal of Clinical Microbiology, 45(2), 409-14.
Kong, Y., Cave, M.D., Zhang, L., Foxman, B., Marrs, C.F., Bates, J.H., Yang, Z.H. (November, 2006). Population-based study of deletions in five different genomic regions of Mycobacterium tuberculosis and possible clinical relevance of the deletions., 44(11), 3940-6.
Yang, Z, Yang, D., Kong, Y., Zhang, L., Marrs, C. F., Foxman, B., Bates, J.H., Wilson, F., and Cave, M.D. (June, 2005). Clinical relevance of Mycobacterium tuberculosis plcD gene mutations. American Journal of Respiratory and Critical Care Medicine, Jun 15;171(12), 1436-42.
Yang, Z., Durmaz, R., Yang, D., Gunal, S., Zhang, L., Foxman, B., Sanic, A., and Marrs, C.F. (2005). Simultaneous detection of isoniazid, rifampin, and ethambutol resistance of Mycobacterium tuberculosis by a single multiplex allele-specific PCR assay. Diagnostic Microbiology and Infectious Disease
Yang, Z., Kong, Y., Wilson, F., Foxman, B., Fowler, A.H., Marrs, C.F., Cave, M.D., and Bates, J.H. (January, 2004). Identification of risk factors for extrapulmonary tuberculosis Clinical Infectious Diseases, Jan 15;38(2), 199-205.
Yang, Z.H., Barnes, P.F., Chaves, F., Eisenach, K.D., Weis, S., Bates, J.H. and Cave, M.D. (1998). Diversity of DNA fingerprints of Mycobacterium tuberculosis isolates in the United States Journal of Clinical Microbiology, 35(4): 1003-1007.
Yang, Z.H., Bates, J.H., Eisenach, K.D., and Cave, M.D. (May, 2001). Secondary typing of Mycobacterium tuberculosis isolates with matching IS6110 fingerprints from different geographic regions of the U. S. Journal of Clinical Microbiology, 39(5), 1691-1695.
Professional Affiliations
Member, American Society for Microbiology
Member, American Public Health Association
International Union against Tuberculosis and Lung Disease
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