Transmission & Surveillance

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In the United States and elsewhere, people tend to get tested later because they're worried about the stigma associated with HIV.

The earlier people get tested for HIV, the greater the chance they won’t spread the disease. That’s the driving idea behind James Koopman’s work of the past 24 years. Koopman, a professor of epidemiology at SPH, is developing new methods for a science of infectious transmissions, and HIV/AIDS is a key focus of his research. Using data from a Montreal surveillance system set up by the province of Quebec to genetically sequence HIV isolates, Koopman and his research team are identifying the patterns of HIV transmission during early stages of the infection, with the hope that their findings can lead to new means of slowing the AIDS epidemic.

Because the creators of the Montreal surveillance system have gone to great lengths to respect the human rights of HIV-infected people in high-risk groups such as gay males and drug users, members of these vulnerable minorities are much more willing to be tested early. That’s “a boon for our investigation,” Koopman says, noting that early-stage HIV samples are invaluable because they better reflect the chains of transmission.

The Montreal data has shed important new light on temporal and spatial patterns of transmission and allowed Koopman and his team to begin to understand a number of factors, including the degree to which small outbreaks of AIDS are related to primary infections, the extent of transmission in the early stages of the disease, and the various types of transmission chains that contribute to the spread of AIDS.

 

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