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HIPAA

Baylin Group - Nutritional Epidemiology and Cardiovascular Disease

Toward a New Molecular Classification of Cancer

Principal Investigators

Jeremy Taylor, Kathleen Cho, Samir Hanash 

Co-Principal Investigator

Sharon Kardia 

Co-Investigator

Kerby Shedden 

Funding Sources

National Cancer Institute (NCI)

Status

Current

About this Project

For most types of cancer histopathology is insufficient to predict disease progression and clinical outcome. Working with researchers at the UM Cancer Center, we helped develop and apply methods for identifying genes expression profiles based on microarray analysis that could be used for identifying histological subtypes of cancers, distinguishing between cancer stages, and predicting patient survival. We have used a wide range of methods to study those gene expression patterns including machine-learning algorithms, scan statistics, markov-chain monte carlo methods, and risk index methods.

Image from Beer, et al. Nature Medicine  8, 816 - 824 (2002)

Image from Beer, et al. Nature Medicine 8, 816 - 824 (2002)