Example where assessment of virus reproduction dynamics was important
The two most cited papers in all 1996.
- Ho DD, Neumann AU, Perelson AS, Chen W, Leonard JM, Markowitz M. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature 1995;373(6510):123-6
- Wei X Ghosh SK Taylor ME Johnson VA Emini EA Deutsch P Lifson JD Bonhoeffer S Nowak MA Hahn BH et al. Viral dynamics in human immunodeficiency virus type 1 infection. Nature 1995;373(6510):117-22
- Instead of initial conditions, equilibrium conditions were assessed by introducing a change at equilibrium and observing the speed of changes.