Elaborating and Refining Estimates of Virus Reproduction Dynamics
Break reproduction rate into
- Cellular phase controlled by cellular immune responses
- Free virus phase more influenced by antibody responses
Add other aspects of reality
- Latently infected cells
- Latent period between cell infection and virus production
- Latent period after Rx before virus production shut off
- Incomplete effect of Rx
- Non-homogeneous mixing between cells and virus