Richard Megumi Watanabe
Last Update: March 20, 1999
PERSONAL INFORMATION Business Address University of Michigan School of Public Health Department of Biostatistics 1420 Washington Heights Ann Arbor, MI 48109-2029 Business Phone Voice: (734) 647-3944 FAX: (734) 763-2215 E-mail rwatt@sph.umich.edu Date and Place of Birth September 7, 1962, San Fernando, CA Citizenship U.S.A. Marital Status Single EDUCATION University of Southern California 1986 B.S., Biological Sciences University of Southern California 1989 M.S., Applied Biometry Thesis Title: Mathematical Modeling of Insulin Secretion: Issues of Model Complexity University of Southern California 1995 Ph.D., Exercise Physiology Dissertation Title: Assessment of b-cell function in vivo FELLOWSHIPS AND GRANTS NIH Predoctoral Training Fellowship 1990-1995 National Institutes of Aging, T32-AG00093 Training in Aging NIH Postdoctoral Training Fellowship 1995-1996 National Center for Human Genome Research, T32-HG00040 Institutional Training Grant in Genomic Science NIH National Research Service Award 9/96-8/98 National Institutes of Diabetes, Digestive, and Kidney Disease, F32-DK09525 Positional Cloning of Genes for NIDDM Career Development Award 7/98-6/01 American Diabetes Association Localization of Type-2 Diabetes Susceptibility Loci Through Analysis of Quantitative Traits HONORS Serono Symposia In-Training Award, First Prize 1990 Pacific Coast Fertility Society, 38th Annual Meeting Student Award for Meritorious Research 1990 American Federation for Clinical Research, Western Society Who's Who in America, West 1993-1996 Who's Who in California 1993-1995 American Federation for Clinical Research Medical Student Award 1994 Michaela Modan Memorial Award for Outstanding Research in 1995 Epidemiology, Complications, or Prevention of Diabetes American Diabetes Association, Council on Epidemiology and Statistics Who's Who in America, Midwest 1997 WORK EXPERIENCE Statistical Analyst and Computer Programmer 1985-1989 Los Angeles County/USC Medical Center Women's Hospital National Institutes of Child Health and Human Development Contract N01-HD-52906 "Measures of glucose tolerance and lipid metabolism in users of norgestrel-containing oral contraceptives" NIH Predoctoral Trainee 1990-1995 University of Southern California, School of Medicine Department of Physiology & Biophysics National Institutes of Aging, T32-AG00093 “Training in Aging” The Insulin Resistance Atherosclerosis Study (“IRAS”) 1991-1995 Director, Kinetic Core Participating Member, Steering Committee Member, Laboratory Quality Control Committee University of Southern California, School of Medicine Department of Physiology & Biophysics, Metabolic Research Unit NIH Cooperative Agreement U01-HL47890-01 "Insulin, insulin resistance, hyperglycemia and cardiovascular disease" The Finland-US Investigation of NIDDM (“FUSION”) 1994-1995 Kinetic Analyst University of Southern California, School of Medicine Department of Physiology & Biophysics, Metabolic Research Unit National Center for Human Genome Research Contract N01-HG-42104 “Mapping genes for non-insulin-dependent diabetes mellitus study population” NIH Postdoctoral Trainee 1995-1996 University of Michigan, School of Public Health Department of Biostatistics National Center for Human Genome Research, T32-HG00040 "Institutional Training Grant in Genomic Science" NIH Postdoctoral Fellow 1996-1998 University of Michigan, School of Public Health Department of Biostatistics National Institutes of Diabetes, Digestive, and Kidney Disease, F32-DK09525 "Positional Cloning of Genes for NIDDM" The International Type 2 Diabetes Linkage Consortium 1998-present Member, Analysis Committee University of Michigan, School of Public Health Deapartment of Biostatistics Research Investigator 1998-present University of Michigan, School of Public Health Department of Biostatistics RECENT REVIEWER FOR: Diabetes Diabetes Care Diabetologia American Journal of Physiology American Journal of Clinical Endocrinology and Metabolism Human Heredity American Journal of Hypertension Metabolism University of Michigan DRTC: Pilot/Feasibility Grant Competition Department of Veterans Affairs Medical Research Service: Merit Review Boards Department of Veterans Affairs Medical Reserach Service: Career Development Awards Canadian Diabetes Association: Charles H. Best Trust Fund SOCIETY MEMBERSHIPS American Diabetes Association (Professional Section) American Association for the Advancement of Science (Student Member) The American Physiological Society (Student Member) The Americal Federation for Clinical Research The European Association for the Study of Diabetes The American Society of Human Genetics INVITED TALKS Computers in Diabetes Conference '92, Kalory Vary, Czechoslovakia September, 1992 Computer-based Approaches to Assess Insulin Secretion In Vivo Third International Symposium on Minimal Modeling, Baton Rouge, Louisiana June, 1994 Kinetic analysis of both plasma insulin and C-peptide dynamics provides accurate assessment of in vivo insulin secretion rates American Diabetes Association California Affiliate, 10th Annual Research Symposium, Irvine, California June, 1995 Assessment of b-cell Function: Is Knowning Insulin Secretion Enough? Fourth International Symposium on Minimal Modeling, Copenhagen, Denmark July, 1997 Familiality of Minimal Model-derived Quantitative Metabolic Traits in a Finnish Cohort SEMINARS LADSEB-CNR, Research Institute for System Dynamics and Bioengineering, Padova, Italy September, 1992 Computer-based Approaches to Assess Insulin Secretion In Vivo September, 1992 Effect of Oral Contraceptives on Carbohydrate Metabolism: A Modeling-Based Approach October, 1994 Lactate Kinetics Following Intravenous Glucose in Normal Humans: An Adaptation of the Minimal Model Joslin Diabetes Center, Epidemiology Group March, 1995 The Combined Model Approach for Assessment of Insulin Secretion in vivo University of Michigan, Department of Biostatistics April, 1995 Quantifying Factors which Regulate Glucose Tolerance University of Tsukuba, Department of Biochemisty of Exercise and Nutrition, Tsukuba, Japan July, 1996 Adaptation and Application of the Minimal Model to Epidemiologic Studies NIDDK, NIH, Phoenix, Diabetes and Arthritis Epidemiology Section July, 1998 The Search for Genes for Type 2 Diabetes: The FUSION Experience Vanderbilt University Medical Center, Department of Molecular Physiology and Biophysics August, 1998 The Search for Genes for Type 2 Diabetes: The FUSION Experience Indiana University School of Medicine, Department of Medical and Molecular Genetics August, 1998 The Search for Genes for Type 2 Diabetes: The FUSION Experience University of Washington, Department of Medicine, Division of Metabolism, Endocrinology, & Nutrition October, 1998 The Search for Genes for Type 2 Diabetes: The FUSION Experience University of Maryland, Department of Medicine, Division of Diabetes, Obesity, & Nutrition February, 1999 Integrating quantitative trait information into the search for type 2 diabetes susceptibility genes Pennington Biomedical Research Center February, 1999 Integrating quantitative trait information into the search for type 2 diabetes susceptibility genes University of Chicago, Department of Human Genetics March, 1999 Integrating quantitative trait information into the search for type 2 diabetes susceptibility genes PUBLICATIONS Full Papers - Peer Reviewed 1. Watanabe RM, Volund A, Roy S, and Bergman RN Prehepatic b-cell secretion during the intravenous glucose tolerance test in humans: Application of a combined model of insulin and C-peptide kinetics. J Clin Endocrinol Metab 69:790-797, 1988. 2. Watanabe RM, Volund A, and Bergman RN Intravenous insulin infusion to simulate subcutaneous absorption: Bioavailability and metabolic sequelae. Diabetes Care 14:1021-1030, 1991. 3. Buyalos RP, Geffner ME, Bersch N, Judd HL, Watanabe RM, Bergman RN, Golde DW Insulin and insulin-like growth factor-I responsiveness in polycystic ovarian syndrome. Fertil Steril 57:796-803, 1992. 4. Haffner SM, Stern MP, Watanabe R, Bergman RN Relationship of insulin clearance and secretion to insulin sensitivity in non-diabetic Mexican Americans. Europ J Clin Invest 22:147-153, 1992. 5. Buyalos RP, Geffner ME, Watanabe RM, Bergman RN, Gornbein JA, Judd HL The influence of luteinizing hormone and insulin on sex steroids and sex hormone-binding globulin in the polycystic ovarian syndrome. Fertil Steril 60:626-633, 1993. 6. Wing RR, Blair EH, Bononi P, Marcus MD, Watanabe R, Bergman RN Effects of caloric restriction per se versus weight loss on glycemic control and insulin sensitivity in obese patients with NIDDM. Diabetes Care 17:30-36, 1994. 7. Hamilton-Wessler M, Bergman RN, Halter JB, Watanabe RM, Donovan CM Hepatic glucosensors are essential for the full sympathetic response to deep hypoglycemia in conscious dogs. Diabetes 43:1052-1060, 1994. 8. Saad MF, Anderson RL, Laws A, Watanabe RM, Kades WW, Chen Y-DI, Sands RE, Pei D, Savage PJ, Bergman RN for the Insulin Resistance Atherosclerosis Study. A comparison between the minimal model and the glucose clamp in the assessment of insulin sensitivity across the spectrum of glucose tolerance. Diabetes 43:1114-1121, 1994. 9. Watanabe RM, Azen CG, Roy S, Perlman JA, Bergman RN Defects in carbohydrate metabolism in oral contraceptive users without apparent metabolic risk factors. J Clin Endo Metab 79:1277-1283, 1994. 10. Watanabe RM, Lovejoy J, DiGirolamo M, Bergman RN Insulin sensitivity accounts for glucose and lactate kinetics following intravenous glucose injection. Diabetes 44:954-962, 1995. 11. Mykkanen L, Haffner SM, Ronnemaa T, Watanabe RM, Laakso M Relationship of plasma insulin concentratio and insulin sensitivity to blood pressure. Is it modified by obesity? J Hypertension 14:399-405, 1996. 12. Watanabe RM, Steil GM, Bergman RN Critical evaluation of the Combined Model approach for estimation of pre-hepatic insulin secretion by Monte-Carlo simulation. Am J Physiol 274:E172-E183, 1998. 13. Valle T, Tuomilehto J, Bergman RN, Ghosh S, Hauser ER, Eriksson J, Nylund S, Kohtamäki K, Tuomilehto-Wolf E, Toivanen L, Vidgren G, Ehnholm C, Blaschak J, Langefeld CD, Watanabe RM, Magnuson V, Ally DS, Hagopian W, Ross E, Buchanan TA, Collins F, and Boehnke M. Mapping genes for non-insulin dependent diabetes mellitus: Design of the Finland-United States investigation of NIDDM genetics (FUSION) study. Diabetes Care 21:949-958, 1998. 14. Ghosh S, Hauser ER, Magnuson VL, Valle T, Ally DS, Karanjawala ZE, Rayman JB, Knapp JI, Musick A, Tannenbaum J, Te C, Eldridge W, Shapiro S, Musick T, Martin C, So A, Witt A, Blaschak-Harvan J, Watanabe RM, Hagopian W, Eriksson J, Nylund S, Kohtamaki K, Tuomilehto-Wolf E, Toivanen L, Vidgren G, Ehnholm C, Bergman R, Tuomilehto J, Collins FS, and Boehnke M. A large sample of Finnish diabetic sib-pairs reveals no evidence for a NIDDM susceptibility locus at 2qter. J Clin Invest 102:704-709, 1998. 15. Ghosh S, Langefeld CD, Ally DS, Watanabe RM, Hauser ER, Magnuson VL, Nylund SJ, Valle T, Eriksson J, Bergman RN, Tuomilehto J, Collins FS, and Boehnke M. The W64R variant of the (3-adrenergic receptor is not associated with type 2 diabetes or obesity in a large Finnish sample. Diabetologia 42:238-244, 1999. 16. Ghosh S, Watanabe RM, Hauser ER, Langefeld CD, Valle T, Magnuson V, Ally D, Erdos M, Balow J, Kohtamaki K, Musick A, Te C, Tannenbaum J, Eldridge W, Shapiro S, Martin C, Witt A, So A, Chang J, Shurtleff B, Porter R, Kudelko K, Unni A, Segal L, Sharaf R, Blaschak-Harvan J, Tuomilehto-Wolf E, Hagopian W, Tuomilehto J, Bergman RN, Collins FS, and Boehnke M. Analysis of chromosome 20 for type 2 diabetes and related traits reveals evidence for linkage to both 20p and 20q in a large Finnish sample. Proc Nat Acad Sci 96: 2198-2203, 1999. 17. Watanabe RM, Hauser ER, Valle T, Eriksson J, Bergman RN, Boehnke M for the Finland-United States Investigation of NIDDM Genetics Study. Familiality of quantitative metabolic traits in Finnish families with non-insulin-dependent diabetes mellitus. Human Heredity (in press), 1999. 18. Watanabe RM, Ghosh S, Birznieks G, Duren WL, and Mitchell BD. Application of an ordered subset analysis approach to the genetics of alcoholism. Genet Epidemiol (in press), 1999. 19. Mitchell BD, Ghosh S, Watanabe RM, Slifer SH, Hsueh WC, and Birznieks G. Identifying influential individuals in linkage analysis: Application to a quantitative trait locus detected in the COGA data. Genet Epidemiol (in press), 1999. 20. Birznieks G, Ghosh S, Watanabe RM, Mitchell BD. The effect of phenotypic variation on detection of linkage in the COGA data. Genet Epidemiol (in press), 1999. 21. Bergman RN, Watanabe RM, D'Agostino Jr. R, Howard G for the Insulin Resistance Atherosclerosis Study Hyperbolic insulin secretion/sensitivity relation with differing glycemic status: severe insulin secretory defect with imparied glucose tolerance. Diabetes (under review), 1999. 22. Watanabe RM, Bergman RN Validation of the improved Combined Model approach for estimation of pre-hepatic insulin secretion in vivo. Diabetes (under review), 1999. Reviews - Peer Reviewed 1. Best JD, Kahn SE, Ader M, Watanabe RM, Ni T-C, and Bergman RN Role of glucose effectiveness in the determination of glucose tolerance. Diabetes Care 19:1018-1030, 1996. Reviews - Invited 1. Bergman RN, Hope ID, Yang YJ, Watanabe RM, Meador MA, Youn JH, Ader M Assessment of insulin sensitivity in vivo: A critical review. Diab Metab Rev 5:411-429, 1989. 2. Bergman RN, Steil GM, Bradley DC, Watanabe RM Modeling insulin action in vivo. Ann Rev Physiol 54:861-883, 1992. 3. Bergman RN, Watanabe R, Rebrin K, Ader M, and Steil G Toward an integrated phenotype in pre-NIDDM. Diabetic Med 13(Suppl 6):S63-S77, 1996. Book Chapters 1. Watanabe RM, Steil GM The Combined Model: Assessment of Insulin Secretion from a Single Protocol. In: Bergman RN, Lovejoy J, eds. The Minimal Model Approach and Determinants of Glucose Tolerance Baton Rouge: Lousiana State University Press, Baton Rouge, LA, 1997.
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