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Publication Index
Nair RP, Ding J, Duffin KC, Helms C, Voorhees JJ, Krueger GG, Bowcock AM, Abecasis GR and Elder JT
(2009).
Psoriasis bench to bedside: genetics meets immunology.
Arch Dermatol 145:462-4
[PDF]
Tanaka T, Scheet P, Giusti B, Bandinelli S, Piras MG, Usala G, Lai S, Mulas A, Corsi AM, Vestrini A, Sofi F, Gori AM, Abbate R, Guralnik J, Singleton A, Abecasis GR, Schlessinger D, Uda M and Ferrucci L
(2009).
Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations.
Am J Hum Genet 84:477-82
[Abstract]
[PDF]
Pfeufer A, Sanna S, Arking DE, Muller M, Gateva V, Fuchsberger C, Ehret GB, Orru M, Pattaro C, Kottgen A, Perz S, Usala G, Barbalic M, Li M, Putz B, Scuteri A, Prineas RJ, Sinner MF, Gieger C, Najjar SS, Kao WH, Muhleisen TW, Dei M, Happle C, Mohlenkamp S, Crisponi L, Erbel R, Jockel KH, Naitza S, Steinbeck G, Marroni F, Hicks AA, Lakatta E, Muller-Myhsok B, Pramstaller PP, Wichmann HE, Schlessinger D, Boerwinkle E, Meitinger T, Uda M, Coresh J, Kaab S, Abecasis GR and Chakravarti A
(2009).
Common variants at ten loci modulate the QT interval duration in the QTSCD Study.
Nat Genet 41:407-14
[Abstract]
[PDF]
Cookson W, Liang L, Abecasis G, Moffatt M and Lathrop M
(2009).
Mapping complex disease traits with global gene expression.
Nat Rev Genet 10:184-94
[Abstract]
[PDF]
Huang L, Li Y, Singleton AB, Hardy JA, Abecasis G, Rosenberg NA and Scheet P
(2009).
Genotype-imputation accuracy across worldwide human populations.
Am J Hum Genet 84:235-50
[Abstract]
[PDF]
Nair RP, Duffin KC, Helms C, Ding J, Stuart PE, Goldgar D, Gudjonsson JE, Li Y, Tejasvi T, Feng BJ, Ruether A, Schreiber S, Weichenthal M, Gladman D, Rahman P, Schrodi SJ, Prahalad S, Guthery SL, Fischer J, Liao W, Kwok PY, Menter A, Lathrop GM, Wise CA, Begovich AB, Voorhees JJ, Elder JT, Krueger GG, Bowcock AM and Abecasis GR
(2009).
Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.
Nat Genet 41:199-204
[Abstract]
[PDF]
de Cid R, Riveira-Munoz E, Zeeuwen PL, Robarge J, Liao W, Dannhauser EN, Giardina E, Stuart PE, Nair R, Helms C, Escaramis G, Ballana E, Martin-Ezquerra G, den Heijer M, Kamsteeg M, Joosten I, Eichler EE, Lazaro C, Pujol RM, Armengol L, Abecasis G, Elder JT, Novelli G, Armour JA, Kwok PY, Bowcock A, Schalkwijk J and Estivill X
(2009).
Deletion of the late cornified envelope LCE3B and LCE3C genes as a susceptibility factor for psoriasis.
Nat Genet 41:211-5
[Abstract]
[PDF]
Liang L, Chen WM, Sham PC and Abecasis GR
(2009).
Variance Components Linkage Analysis with Repeated Measurements.
Hum Hered 67:237-247
[Abstract]
[PDF]
[Web]
Chen W, Liang L and Abecasis GR
(2009).
GWAS GUI: graphical browser for the results of whole-genome association studies with high-dimensional phenotypes.
Bioinformatics 25:284-5
[Abstract]
[PDF]
[Web]
Willer CJ, Speliotes EK, Loos RJ, Li S, Lindgren CM, Heid IM, Berndt SI, Elliott AL, Jackson AU, Lamina C, Lettre G, Lim N, Lyon HN, McCarroll SA, Papadakis K, Qi L, Randall JC, Roccasecca RM, Sanna S, Scheet P, Weedon MN, Wheeler E, Zhao JH, Jacobs LC, Prokopenko I, Soranzo N, Tanaka T, Timpson NJ, Almgren P, Bennett A, Bergman RN, Bingham SA, Bonnycastle LL, Brown M, Burtt NP, Chines P, Coin L, Collins FS, Connell JM, Cooper C, Smith GD, Dennison EM, Deodhar P, Elliott P, Erdos MR, Estrada K, Evans DM, Gianniny L, Gieger C, Gillson CJ, Guiducci C, Hackett R, Hadley D, Hall AS, Havulinna AS, Hebebrand J, Hofman A, Isomaa B, Jacobs KB, Johnson T, Jousilahti P, Jovanovic Z, Khaw KT, Kraft P, Kuokkanen M, Kuusisto J, Laitinen J, Lakatta EG, Luan J, Luben RN, Mangino M, McArdle WL, Meitinger T, Mulas A, Munroe PB, Narisu N, Ness AR, Northstone K, O'Rahilly S, Purmann C, Rees MG, Ridderstrale M, Ring SM, Rivadeneira F, Ruokonen A, Sandhu MS, Saramies J, Scott LJ, Scuteri A, Silander K, Sims MA, Song K, Stephens J, Stevens S, Stringham HM, Tung YC, Valle TT, Van Duijn CM, Vimaleswaran KS, Vollenweider P, Waeber G, Wallace C, Watanabe RM, Waterworth DM, Watkins N, Witteman JC, Zeggini E, Zhai G, Zillikens MC, Altshuler D, Caulfield MJ, Chanock SJ, Farooqi IS, Ferrucci L, Guralnik JM, Hattersley AT, Hu FB, Jarvelin MR, Laakso M, Mooser V, Ong KK, Ouwehand WH, Salomaa V, Samani NJ, Spector TD, Tuomi T, Tuomilehto J, Uda M, Uitterlinden AG, Wareham NJ, Deloukas P, Frayling TM, Groop LC, Hayes RB, Hunter DJ, Mohlke KL, Peltonen L, Schlessinger D, Strachan DP, Wichmann HE, McCarthy MI, Boehnke M, Barroso I, Abecasis GR and Hirschhorn JN
(2009).
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.
Nat Genet 41:25-34
[Abstract]
[PDF]
Prokopenko I, Langenberg C, Florez JC, Saxena R, Soranzo N, Thorleifsson G, Loos RJ, Manning AK, Jackson AU, Aulchenko Y, Potter SC, Erdos MR, Sanna S, Hottenga JJ, Wheeler E, Kaakinen M, Lyssenko V, Chen WM, Ahmadi K, Beckmann JS, Bergman RN, Bochud M, Bonnycastle LL, Buchanan TA, Cao A, Cervino A, Coin L, Collins FS, Crisponi L, de Geus EJ, Dehghan A, Deloukas P, Doney AS, Elliott P, Freimer N, Gateva V, Herder C, Hofman A, Hughes TE, Hunt S, Illig T, Inouye M, Isomaa B, Johnson T, Kong A, Krestyaninova M, Kuusisto J, Laakso M, Lim N, Lindblad U, Lindgren CM, McCann OT, Mohlke KL, Morris AD, Naitza S, Orru M, Palmer CN, Pouta A, Randall J, Rathmann W, Saramies J, Scheet P, Scott LJ, Scuteri A, Sharp S, Sijbrands E, Smit JH, Song K, Steinthorsdottir V, Stringham HM, Tuomi T, Tuomilehto J, Uitterlinden AG, Voight BF, Waterworth D, Wichmann HE, Willemsen G, Witteman JC, Yuan X, Zhao JH, Zeggini E, Schlessinger D, Sandhu M, Boomsma DI, Uda M, Spector TD, Penninx BW, Altshuler D, Vollenweider P, Jarvelin MR, Lakatta E, Waeber G, Fox CS, Peltonen L, Groop LC, Mooser V, Cupples LA, Thorsteinsdottir U, Boehnke M, Barroso I, Van Duijn C, Dupuis J, Watanabe RM, Stefansson K, McCarthy MI, Wareham NJ, Meigs JB and Abecasis GR
(2009).
Variants in MTNR1B influence fasting glucose levels.
Nat Genet 41:77-81
[Abstract]
[PDF]
Kathiresan S, Willer CJ, Peloso GM, Demissie S, Musunuru K, Schadt EE, Kaplan L, Bennett D, Li Y, Tanaka T, Voight BF, Bonnycastle LL, Jackson AU, Crawford G, Surti A, Guiducci C, Burtt NP, Parish S, Clarke R, Zelenika D, Kubalanza KA, Morken MA, Scott LJ, Stringham HM, Galan P, Swift AJ, Kuusisto J, Bergman RN, Sundvall J, Laakso M, Ferrucci L, Scheet P, Sanna S, Uda M, Yang Q, Lunetta KL, Dupuis J, de Bakker PI, O'Donnell CJ, Chambers JC, Kooner JS, Hercberg S, Meneton P, Lakatta EG, Scuteri A, Schlessinger D, Tuomilehto J, Collins FS, Groop L, Altshuler D, Collins R, Lathrop GM, Melander O, Salomaa V, Peltonen L, Orho-Melander M, Ordovas JM, Boehnke M, Abecasis GR, Mohlke KL and Cupples LA
(2009).
Common variants at 30 loci contribute to polygenic dyslipidemia.
Nat Genet 41:56-65
[Abstract]
[PDF]
[Web]
Tanaka T, Shen J, Abecasis GR, Kisialiou A, Ordovas JM, Guralnik JM, Singleton A, Bandinelli S, Cherubini A, Arnett D, Tsai MY and Ferrucci L
(2009).
Genome-wide association study of plasma polyunsaturated fatty acids in the InCHIANTI Study.
PLoS Genet 5:e1000338
[Abstract]
[PDF]
Mohlke KL, Boehnke M and Abecasis GR
(2008).
Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants.
Hum Mol Genet 17:R102-8
[Abstract]
[PDF]
Gaulton KJ, Willer CJ, Li Y, Scott LJ, Conneely KN, Jackson AU, Duren WL, Chines PS, Narisu N, Bonnycastle LL, Luo J, Tong M, Sprau AG, Pugh EW, Doheny KF, Valle TT, Abecasis GR, Tuomilehto J, Bergman RN, Collins FS, Boehnke M and Mohlke KL
(2008).
Comprehensive association study of type 2 diabetes and related quantitative traits with 222 candidate genes.
Diabetes 57:3136-44
[Abstract]
[PDF]
Orho-Melander M, Melander O, Guiducci C, Perez-Martinez P, Corella D, Roos C, Tewhey R, Rieder MJ, Hall J, Abecasis G, Tai ES, Welch C, Arnett DK, Lyssenko V, Lindholm E, Saxena R, de Bakker PI, Burtt N, Voight BF, Hirschhorn JN, Tucker KL, Hedner T, Tuomi T, Isomaa B, Eriksson KF, Taskinen MR, Wahlstrand B, Hughes TE, Parnell LD, Lai CQ, Berglund G, Peltonen L, Vartiainen E, Jousilahti P, Havulinna AS, Salomaa V, Nilsson P, Groop L, Altshuler D, Ordovas JM and Kathiresan S
(2008).
Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations.
Diabetes 57:3112-21
[Abstract]
[PDF]
Arnaud-Lopez L, Usala G, Ceresini G, Mitchell BD, Pilia MG, Piras MG, Sestu N, Maschio A, Busonero F, Albai G, Dei M, Lai S, Mulas A, Crisponi L, Tanaka T, Bandinelli S, Guralnik JM, Loi A, Balaci L, Sole G, Prinzis A, Mariotti S, Shuldiner AR, Cao A, Schlessinger D, Uda M, Abecasis GR, Nagaraja R, Sanna S and Naitza S
(2008).
Phosphodiesterase 8B Gene Variants Are Associated with Serum TSH Levels and Thyroid Function.
Am J Hum Genet 82:1270-80
[Abstract]
[PDF]
Chen WM, Erdos MR, Jackson AU, Saxena R, Sanna S, Silver KD, Timpson NJ, Hansen T, Orru M, Grazia Piras M, Bonnycastle LL, Willer CJ, Lyssenko V, Shen H, Kuusisto J, Ebrahim S, Sestu N, Duren WL, Spada MC, Stringham HM, Scott LJ, Olla N, Swift AJ, Najjar S, Mitchell BD, Lawlor DA, Smith GD, Ben-Shlomo Y, Andersen G, Borch-Johnsen K, Jorgensen T, Saramies J, Valle TT, Buchanan TA, Shuldiner AR, Lakatta E, Bergman RN, Uda M, Tuomilehto J, Pedersen O, Cao A, Groop L, Mohlke KL, Laakso M, Schlessinger D, Collins FS, Altshuler D, Abecasis GR, Boehnke M, Scuteri A and Watanabe RM
(2008).
Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels.
J Clin Invest 118:2620-8
[Abstract]
[PDF]
Loos RJ, Lindgren CM, Li S, Wheeler E, Zhao JH, Prokopenko I, Inouye M, Freathy RM, Attwood AP, Beckmann JS, Berndt SI, Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial (Jacobs KB, Chanock SJ, Hayes Bergmann S, Bergmann S, Bennett AJ, Bingham SA, Bochud M, Brown M, Cauchi S, Connell JM, Cooper C, Smith GD, Day I, Dina C, De S, Dermitzakis ET, Doney AS, Elliott KS, Elliott P, Evans DM, Sadaf Farooqi I, Froguel P, Ghori J, Groves CJ, Gwilliam R, Hadley D, Hall AS, Hattersley AT, Hebebrand J, Heid IM, KORA (Lamina C, Gieger C, Illig T, Meitinger T, Wichmann HE), Herrera B, Hinney A, Hunt SE, Jarvelin MR, Johnson T, Jolley JD, Karpe F, Keniry A, Khaw KT, Luben RN, Mangino M, Marchini J, McArdle WL, McGinnis R, Meyre D, Munroe PB, Morris AD, Ness AR, Neville MJ, Nica AC, Ong KK, O'Rahilly S, Owen KR, Palmer CN, Papadakis K, Potter S, Pouta A, Qi L, Nurses' Health Study (Kraft P, Hankinson SE, Hunter DJ, Hu FB), Randall JC, Rayner NW, Ring SM, Sandhu MS, Scherag A, Sims MA, Song K, Soranzo N, Speliotes EK, Diabetes Genetics Initiative (Lyon HN, Voight BF, Ridderstrale M, Groop L), Syddall HE, Teichmann SA, Timpson NJ, Tobias JH, Uda M, SardiNIA Study (Scheet P, Sanna S, Abecasis GR, Albai G, Nagaraja R, Schlessinger D), Vogel CI, Wallace C, Waterworth DM, Weedon MN, Willer CJ, FUSION (Jackson AU, Tuomilehto J, Collins FS, Boehnke M, Mohlke KL), Wraight, Yuan X, Zeggini E, Hirschhorn JN, Strachan DP, Ouwehand WH, Caulfield MJ, Samani NJ, Frayling TM, Vollenweider P, Waeber G, Mooser V, Deloukas P, McCarthy MI, Wareham NJ and Barroso I
(2008).
Common variants near MC4R are associated with fat mass, weight and risk of obesity.
Nat Genet 40:768-75
[Abstract]
[PDF]
Lettre G, Jackson AU, Gieger C, Schumacher FR, Berndt SI, Sanna S, Eyheramendy S, Voight BF, Butler JL, Guiducci C, Illig T, Hackett R, Heid IM, Jacobs KB, Lyssenko V, Uda M, Boehnke M, Chanock SJ, Groop LC, Hu FB, Isomaa B, Kraft P, Peltonen L, Salomaa V, Schlessinger D, Hunter DJ, Hayes RB, Abecasis GR, Wichmann HE, Mohlke KL and Hirschhorn JN
(2008).
Identification of ten loci associated with height highlights new biological pathways in human growth.
Nat Genet 40:584-91
[Abstract]
[PDF]
Zeggini E, Scott LJ, Saxena R, Voight BF and The DIAGRAM Consortium
(2008).
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.
Nat Genet 40:638-45
[Abstract]
[PDF]
McCarthy MI, Abecasis GR, Cardon LR, Goldstein DB, Little J, Ioannidis JP and Hirschhorn JN
(2008).
Genome-wide association studies for complex traits: consensus, uncertainty and challenges.
Nat Rev Genet 9:356-69
[Abstract]
[PDF]
Willer CJ, Sanna S, Jackson AU, Scuteri A, Bonnycastle LL, Clarke R, Heath SC, Timpson NJ, Najjar SS, Stringham HM, Strait J, Duren WL, Maschio A, Busonero F, Mulas A, Albai G, Swift AJ, Morken MA, Narisu N, Bennett D, Parish S, Shen H, Galan P, Meneton P, Hercberg S, Zelenika D, Chen WM, Li Y, Scott LJ, Scheet PA, Sundvall J, Watanabe RM, Nagaraja R, Ebrahim S, Lawlor DA, Ben-Shlomo Y, Davey-Smith G, Shuldiner AR, Collins R, Bergman RN, Uda M, Tuomilehto J, Cao A, Collins FS, Lakatta E, Lathrop GM, Boehnke M, Schlessinger D, Mohlke KL and Abecasis GR
(2008).
Newly identified loci that influence lipid concentrations and risk of coronary artery disease.
Nat Genet 40:161-9
[Abstract]
[PDF]
[Web]
Sanna S, Jackson AU, Nagaraja R, Willer CJ, Chen WM, Bonnycastle LL, Shen H, Timpson N, Lettre G, Usala G, Chines PS, Stringham HM, Scott LJ, Dei M, Lai S, Albai G, Crisponi L, Naitza S, Doheny KF, Pugh EW, Ben-Shlomo Y, Ebrahim S, Lawlor DA, Bergman RN, Watanabe RM, Uda M, Tuomilehto J, Coresh J, Hirschhorn JN, Shuldiner AR, Schlessinger D, Collins FS, Davey Smith G, Boerwinkle E, Cao A, Boehnke M, Abecasis GR and Mohlke KL
(2008).
Common variants in the GDF5-UQCC region are associated with variation in human height.
Nat Genet 40:198-203
[Abstract]
[PDF]
Uda M, Galanello R, Sanna S, Lettre G, Sankaran VG, Chen W, Usala G, Busonero F, Maschio A, Albai G, Piras MG, Sestu N, Lai S, Dei M, Mulas A, Crisponi L, Naitza S, Asunis I, Deiana M, Nagaraja R, Perseu L, Satta S, Cipollina MD, Sollaino C, Moi P, Hirschhorn JN, Orkin SH, Abecasis GR, Schlessinger D and Cao A
(2008).
Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.
Proc Natl Acad Sci U S A 105:1620-5
[Abstract]
[PDF]
Kanda A, Abecasis G and Swaroop A
(2008).
Inflammation in the pathogenesis of age-related macular degeneration.
Br J Ophthalmol 92:448-50
[Abstract]
[PDF]
Edwards AO, Chen D, Fridley BL, James KM, Wu Y, Abecasis G, Swaroop A, Othman M, Branham K, Iyengar SK, Sivakumaran TA, Klein R, Klein BE and Tosakulwong N
(2008).
Toll-like Receptor Polymorphisms and Age-Related Macular Degeneration.
Invest Ophthalmol Vis Sci 49:1652-9
[Abstract]
The International HapMap Consortium
(2007).
A second generation human haplotype map of over 3.1 million SNPs.
Nature 449:851-61
[Abstract]
[PDF]
[Web]
Li S, Sanna S, Maschio A, Busonero F, Usala G, Mulas A, Lai S, Dei M, Orru M, Albai G, Bandinelli S, Schlessinger D, Lakatta E, Scuteri A, Najjar SS, Guralnik J, Naitza S, Crisponi L, Cao A, Abecasis G, Ferrucci L, Uda M, Chen WM and Nagaraja R
(2007).
The GLUT9 Gene Is Associated with Serum Uric Acid Levels in Sardinia and Chianti Cohorts.
PLoS Genet 3:e194
[Abstract]
[PDF]
Chen WM and Abecasis GR
(2007).
Family-based association tests for genomewide association scans.
Am J Hum Genet 81:913-26
[Abstract]
[PDF]
[Web]
Swaroop A, Branham KE, Chen W and Abecasis G
(2007).
Genetic susceptibility to age-related macular degeneration: a paradigm for dissecting complex disease traits.
Hum Mol Genet 16 Special Review Issue No. 2:R174-82
[Abstract]
[PDF]
Kanda A, Chen W, Othman M, Branham KE, Brooks M, Khanna R, He S, Lyons R, Abecasis GR and Swaroop A
(2007).
A variant of mitochondrial protein LOC387715/ARMS2, not HTRA1, is strongly associated with age-related macular degeneration.
Proc Natl Acad Sci U S A 104:16227-32
[Abstract]
[PDF]
Dixon AL, Liang L, Moffatt MF, Chen W, Heath S, Wong KC, Taylor J, Burnett E, Gut I, Farrall M, Lathrop GM, Abecasis GR and Cookson WO
(2007).
A genome-wide association study of global gene expression.
Nat Genet 39:1202-7
[Abstract]
[PDF]
[Web]
Manolio TA, Rodriguez LL, Brooks L, Abecasis G, Ballinger D, Daly M, Donnelly P, Faraone SV, Frazer K, Gabriel S, Gejman P, Guttmacher A, Harris EL, Insel T, Kelsoe JR, Lander E, McCowin N, Mailman MD, Nabel E, Ostell J, Pugh E, Sherry S, Sullivan PF, Thompson JF, Warram J, Wholley D, Milos PM and Collins FS
(2007).
New models of collaboration in genome-wide association studies: the Genetic Association Information Network.
Nat Genet 39:1045-1051
[Abstract]
[PDF]
Moffatt MF, Kabesch M, Liang L, Dixon AL, Strachan D, Heath S, Depner M, von Berg A, Bufe A, Rietschel E, Heinzmann A, Simma B, Frischer T, Willis-Owen SA, Wong KC, Illig T, Vogelberg C, Weiland SK, von Mutius E, Abecasis GR, Farrall M, Gut IG, Lathrop GM and Cookson WO
(2007).
Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma.
Nature 448 :470-3
[Abstract]
[PDF]
Scuteri A, Sanna S, Chen WM, Uda M, Albai G, Strait J, Najjar S, Nagarajah R, Orru M, Usala G, Dei M, Lai S, Maschio A, Busonero F, Mulas A, Ehret GB, Fink AA, Weder A, Cooper R, Galan P, Chakravarti A, Schlessinger D, Cao A, Lakatta E and Abecasis GR
(2007).
Genome Wide Association Scan shows Genetic Variants in the FTO gene are Associated with Obesity Related Traits
PLoS Genetics 3:1200-10
[Abstract]
[PDF]
ENCODE Project Consortium
(2007).
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project.
Nature 447:799-816
[Abstract]
[PDF]
NCI-NHGRI Working Group on Replication in Association Studies
(2007).
Replicating genotype-phenotype associations.
Nature 447:655-60
[PDF]
Scott LJ, Mohlke KL, Bonnycastle LL, Willer CJ, Li Y, Duren WL, Erdos MR, Stringham HM, Chines PS, Jackson AU, Prokunina-Olsson L, Ding CJ, Swift AJ, Narisu N, Hu T, Pruim R, Xiao R, Li XY, Conneely KN, Riebow NL, Sprau AG, Tong M, White PP, Hetrick KN, Barnhart MW, Bark CW, Goldstein JL, Watkins L, Xiang F, Saramies J, Buchanan TA, Watanabe RM, Valle TT, Kinnunen L, Abecasis GR, Pugh EW, Doheny KF, Bergman RN, Tuomilehto J, Collins FS and Boehnke M
(2007).
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants.
Science 316:1341-5
[Abstract]
[PDF]
Skol AD, Scott LJ, Abecasis GR and Boehnke M
(2007).
Optimal designs for two-stage genome-wide association studies.
Genet Epidemiol 31:776-8
[Abstract]
[PDF]
[Web]
Liang L, Zollner S and Abecasis GR
(2007).
GENOME: a rapid coalescent-based whole genome simulator.
Bioinformatics 23:1565-7
[Abstract]
[PDF]
[Web]
Abecasis G, Tam PK, Bustamante CD, Ostrander EA, Scherer SW, Chanock SJ, Kwok PY and Brookes AJ
(2007).
Human Genome Variation 2006: emerging views on structural variation and large-scale SNP analysis.
Nat Genet 39:153-5
[Abstract]
[PDF]
Li M, Atmaca-Sonmez P, Othman M, Branham KE, Khanna R, Wade MS, Li Y, Liang L, Zareparsi S, Swaroop A and Abecasis GR
(2006).
CFH haplotypes without the Y402H coding variant show strong association with susceptibility to age-related macular degeneration.
Nat Genet 38:1049-1054
[Abstract]
[PDF]
Pilia G, Chen WM, Scuteri A, Orru M, Albai G, Dei M, Lai S, Usala G, Lai M, Loi P, Mameli C, Vacca L, Deiana M, Olla N, Masala M, Cao A, Najjar SS, Terracciano A, Nedorezov T, Sharov A, Zonderman AB, Abecasis GR, Costa P, Lakatta E and Schlessinger D
(2006).
Heritability of Cardiovascular and Personality Traits in 6,148 Sardinians.
PLoS Genet 2:1207-1223
[Abstract]
[PDF]
[Web]
Burdick JT, Chen WM, Abecasis GR and Cheung VG
(2006).
In silico method for inferring genotypes in pedigrees.
Nat Genet 38:1002-4
[Abstract]
[PDF]
Li M, Boehnke M, Abecasis GR and Song PX
(2006).
Quantitative trait linkage analysis using gaussian copulas.
Genetics 173:2317-27
[Abstract]
[PDF]
Fingerlin TE, Abecasis GR and Boehnke M
(2006).
Using sex-averaged genetic maps in multipoint linkage analysis when identity-by-descent status is incompletely known.
Genet Epidemiol 30:384-96
[Abstract]
[PDF]
Chen WM and Abecasis GR
(2006).
Estimating the power of variance component linkage analysis in large pedigrees.
Genet Epidemiol 30:471-84
[Abstract]
[PDF]
Wigginton JE and Abecasis GR
(2006).
An evaluation of the replicate pool method: quick estimation of genome-wide linkage peak p-values.
Genet Epidemiol 30:320-32
[Abstract]
[PDF]
[Web]
Nair RP, Stuart PE, Nistor I, Hiremagalore R, Chia NV, Jenisch S, Weichenthal M, Abecasis GR, Lim HW, Christophers E, Voorhees JJ and Elder JT
(2006).
Sequence and Haplotype Analysis Supports HLA-C as the Psoriasis Susceptibility 1 Gene.
Am J Hum Genet 78:827-51
[Abstract]
[PDF]
Li M, Boehnke M and Abecasis GR
(2006).
Efficient study designs for test of genetic association using sibship data and unrelated cases and controls.
Am J Hum Genet 78:778-92
[Abstract]
[PDF]
[Web]
Skol AD, Scott LJ, Abecasis GR and Boehnke M
(2006).
Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies.
Nat Genet 38:209-13
[Abstract]
[PDF]
[Web]
Qin ZS, Gopalakrishnan S and Abecasis GR
(2006).
An efficient comprehensive search algorithm for tagSNP selection using linkage disequilibrium criteria.
Bioinformatics 22:220-5
[Abstract]
[PDF]
[Web]
Marchini J, Cutler D, Patterson N, Stephens M, Eskin E, Halperin E, Lin S, Qin ZS, Munro HM, Abecasis GR and Donnelly P
(2006).
A comparison of phasing algorithms for trios and unrelated individuals.
Am J Hum Genet 78:437-50
[Abstract]
[PDF]
Stuart P, Nair RP, Abecasis GR, Nistor I, Hiremagalore R, Chia NV, Qin ZS, Thompson RA, Jenisch S, Weichenthal M, Janiga J, Lim HW, Christophers E, Voorhees JJ and Elder JT
(2006).
Analysis of RUNX1 binding site and RAPTOR polymorphisms in psoriasis: no evidence for association despite adequate power and evidence for linkage.
J Med Genet 43:12-7
[Abstract]
[PDF]
The International HapMap Consortium.
(2005).
A haplotype map of the human genome.
Nature 437:1299-320
[Abstract]
[PDF]
Abecasis GR and Wigginton JE
(2005).
Handling marker-marker linkage disequilibrium: pedigree analysis with clustered markers.
Am J Hum Genet 77:754-67
[Abstract]
[PDF]
[Web]
Smith AV, Thomas DJ, Munro HM and Abecasis GR
(2005).
Sequence features in regions of weak and strong linkage disequilibrium.
Genome Res 15:1519-34
[Abstract]
[PDF]
Fisher SA, Abecasis GR, Yashar BM, Zareparsi S, Swaroop A, Iyengar SK, Klein BE, Klein R, Lee KE, Majewski J, Schultz DW, Klein ML, Seddon JM, Santangelo SL, Weeks DE, Conley YP, Mah TS, Schmidt S, Haines JL, Pericak-Vance MA, Gorin MB, Schulz HL, Pardi F, Lewis CM and Weber BH
(2005).
Meta-analysis of genome scans of age-related macular degeneration.
Hum Mol Genet 14:2257-64
[Abstract]
[PDF]
Wigginton JE and Abecasis GR
(2005).
PEDSTATS: descriptive statistics, graphics and quality assessment for gene mapping data.
Bioinformatics 21:3445-7
[Abstract]
[PDF]
[Web]
Cluster 17 Collaboration
(2005).
Fine mapping of the psoriasis susceptibility gene PSORS1: a reassessment of risk associated with a putative risk haplotype lacking HLA-Cw6.
J Invest Dermatol 124:921-30
[Abstract]
Zareparsi S, Branham KE, Li M, Shah S, Klein RJ, Ott J, Hoh J, Abecasis GR and Swaroop A
(2005).
Strong Association of the Y402H Variant in Complement Factor H at 1q32 with Susceptibility to Age-Related Macular Degeneration.
Am J Hum Genet 77:149-53
[Abstract]
[PDF]
Li M, Boehnke M and Abecasis GR
(2005).
Joint Modeling of Linkage and Association: Identifying SNPs Responsible for a Linkage Signal.
Am J Hum Genet 76:934-49
[Abstract]
[PDF]
[Web]
Abecasis GR, Ghosh D and Nichols TE
(2005).
Linkage disequilibrium: ancient history drives the new genetics.
Hum Hered 59:118-24
[Abstract]
[PDF]
Zareparsi S, Buraczynska M, Branham KE, Shah S, Eng D, Li M, Pawar H, Yashar BM, Moroi SE, Lichter PR, Petty HR, Richards JE, Abecasis GR, Elner VM and Swaroop A
(2005).
Toll-like receptor 4 variant D299G is associated with susceptibility to age-related macular degeneration.
Hum Mol Genet 14:1449-55
[Abstract]
Wigginton JE, Cutler DJ and Abecasis GR
(2005).
A note on exact tests of Hardy-Weinberg equilibrium.
Am J Hum Genet 76:887-93
[Abstract]
[PDF]
[Web]
Nistor I, Nair RP, Stuart P, Hiremagalore R, Thompson RA, Jenisch S, Weichenthal M, Abecasis GR, Qin ZS, Christophers E, Lim HW, Voorhees JJ and Elder JT
(2005).
Protein tyrosine phosphatase gene PTPN22 polymorphism in psoriasis: lack of evidence for association.
J Invest Dermatol 125:395-6
[PDF]
Abecasis GR and Zhao Y
(2005).
Algorithmic improvements in gene-mapping.
Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics Section 1.4:Gene Mapping
[Abstract]
[PDF]
Nash MW, Huezo-Diaz P, Williamson RJ, Sterne A, Purcell S, Hoda F, Cherny SS, Abecasis GR, Prince M, Gray JA, Ball D, Asherson P, Mann A, Goldberg D, McGuffin P, Farmer A, Plomin R, Craig IW and Sham PC
(2004).
Genome-wide linkage analysis of a composite index of neuroticism and mood-related scales in extreme selected sibships.
Hum Mol Genet 13:2173-82
[Abstract]
Abecasis G, Cox N, Daly MJ, Kruglyak L, Laird N, Markianos K and Patterson N
(2004).
No bias in linkage analysis.
Am J Hum Genet 75:722-3
[Abstract]
[PDF]
The International HapMap Consortium
(2004).
Integrating ethics and science in the International HapMap Project.
Nat Rev Genet 5:467-75
[Abstract]
[PDF]
Abecasis GR, Yashar BM, Zhao Y, Ghiasvand NM, Zareparsi S, Branham KE, Reddick AC, Trager EH, Yoshida S, Bahling J, Filippova E, Elner S, Johnson MW, Vine AK, Sieving PA, Jacobson SG, Richards JE and Swaroop A
(2004).
Age-related macular degeneration: a high-resolution genome scan for susceptibility Loci in a population enriched for late-stage disease.
Am J Hum Genet 74:482-94
[Abstract]
[PDF]
Fingerlin TE, Boehnke M and Abecasis GR
(2004).
Increasing the Power and Efficiency of Disease-Marker Case-Control Association Studies through Use of Allele-Sharing Information.
Am J Hum Genet 74:432-43
[Abstract]
[PDF]
[Web]
Abecasis GR, Burt RA, Hall D, Bochum S, Doheny KF, Lundy SL, Torrington M, Roos JL, Gogos JA and Karayiorgou M
(2004).
Genomewide scan in families with schizophrenia from the founder population of afrikaners reveals evidence for linkage and uniparental disomy on chromosome 1.
Am J Hum Genet 74:403-17
[Abstract]
[PDF]
Karayiorgou M, Torrington M, Abecasis GR, Pretorius H, Robertson B, Kaliski S, Lay S, Sobin C, Moller N, Lundy SL, Blundell ML, Gogos JA and Roos JL
(2004).
Phenotypic characterization and genealogical tracing in an Afrikaner schizophrenia database.
Am J Med Genet 124B:20-8
[Abstract]
[PDF]
Cardon LR and Abecasis GR
(2003).
Using haplotype blocks to map human complex trait loci.
Trends Genet 19:135-40
[Abstract]
[PDF]
Phillips MS, Lawrence R, Sachidanandam R, Morris AP, Balding DJ, Donaldson MA, Studebaker JF, Ankener WM, Alfisi SV, Kuo FS, Camisa AL, Pazorov V, Scott KE, Carey BJ, Faith J, Katari G, Bhatti HA, Cyr JM, Derohannessian V, Elosua C, Forman AM, Grecco NM, Hock CR, Kuebler JM, Lathrop JA, Mockler MA, Nachtman EP, Restine SL, Varde SA, Hozza MJ, Gelfand CA, Broxholme J, Abecasis GR, Boyce-Jacino MT and Cardon LR
(2003).
Chromosome-wide distribution of haplotype blocks and the role of recombination hot spots.
Nat Genet 33:382-7
[Abstract]
[PDF]
Zhang Y, Leaves NI, Anderson GG, Ponting CP, Broxholme J, Holt R, Edser P, Bhattacharyya S, Dunham A, Adcock IM, Pulleyn L, Barnes PJ, Harper JI, Abecasis G, Cardon L, White M, Burton J, Matthews L, Mott R, Ross M, Cox R, Moffatt MF and Cookson WO
(2003).
Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma.
Nat Genet 34:181-6
[Abstract]
[PDF]
Allen M, Heinzmann A, Noguchi E, Abecasis G, Broxholme J, Ponting CP, Bhattacharyya S, Tinsley J, Zhang Y, Holt R, Jones EY, Lench N, Carey A, Jones H, Dickens NJ, Dimon C, Nicholls R, Baker C, Xue L, Townsend E, Kabesch M, Weiland SK, Carr D, Von Mutius E, Adcock IM, Barnes PJ, Lathrop GM, Edwards M, Moffatt MF and Cookson WO
(2003).
Positional cloning of a novel gene influencing asthma from Chromosome 2q14.
Nat Genet 35:258-63
[Abstract]
[PDF]
Zeegers MP, Rice JP, Rijsdijk FV, Abecasis GR and Sham PC
(2003).
Regression-based sib pair linkage analysis for binary traits.
Hum Hered 55:125-31
[Abstract]
The International HapMap Consortium.
(2003).
The International HapMap Project.
Nature 426:789-96
[Abstract]
[PDF]
Liu H, Abecasis GR, Heath SC, Knowles A, Demars S, Chen YJ, Roos JL, Rapoport JL, Gogos JA and Karayiorgou M
(2002).
Genetic variation in the 22q11 locus and susceptibility to schizophrenia.
Proc Natl Acad Sci U S A 99:16859-64
[Abstract]
[PDF]
Dawson E, Abecasis GR, Bumpstead S, Chen Y, Hunt S, Beare DM, Pabial J, Dibling T, Tinsley E, Kirby S, Carter D, Papaspyridonos M, Livingstone S, Ganske R, Lohmussaar E, Zernant J, Tonisson N, Remm M, Magi R, Puurand T, Vilo J, Kurg A, Rice K, Deloukas P, Mott R, Metspalu A, Bentley DR, Cardon LR and Dunham I
(2002).
A first-generation linkage disequilibrium map of human chromosome 22.
Nature 418:544-548
[Abstract]
[PDF]
[Web]
Sham PC, Purcell S, Cherny SS and Abecasis GR
(2002).
Powerful regression-based quantitative-trait linkage analysis of general pedigrees.
Am J Hum Genet 71:238-53
[Abstract]
[PDF]
[Web]
Zhang W, Collins A, Abecasis GR, Cardon LR and Morton NE
(2002).
Mapping quantitative effects of oligogenes by allelic association.
Ann Hum Genet 66:211-21
[Abstract]
[PDF]
Anderson GG, Leaves NI, Bhattacharyya S, Zhang Y, Walshe V, Broxholme J, Abecasis G, Levy E, Zimmer M, Cox R and Cookson WO
(2002).
Positive association to IgE levels and a physical map of the 13q14 atopy locus.
Eur J Hum Genet 10:266-70
[Abstract]
[PDF]
Abecasis GR, Cherny SS, Cookson WO and Cardon LR
(2002).
Merlin-rapid analysis of dense genetic maps using sparse gene flow trees.
Nat Genet 30:97-101
[Abstract]
[PDF]
[Web]
Cookson WOCM and Abecasis GR
(2001).
Oxford genome screen for asthma-associated traits.
Genet Epidemiol 21:S1-S3
[Abstract]
[PDF]
Cherny, SS, Abecasis, GR, Cookson, WOC, Sham, PC and Cardon, LR
(2001).
The effect of genotype and pedigree error on linkage analysis: Analysis of three asthma genome scans.
Genet Epidemiol 21:S117-S122
[Abstract]
[PDF]
Abecasis, GR, Cardon, LR, Cookson, WOC, Sham, PC and Cherny, SS
(2001).
Association analysis in a variance components framework.
Genet Epidemiol 21:S341-346
[Abstract]
[PDF]
Walley AJ, Chavanas S, Moffatt MF, Esnouf RM, Ubhi B, Lawrence R, Wong K, Abecasis GR, Jones EY, Harper JI, Hovnanian A and Cookson WO
(2001).
Gene polymorphism in Netherton and common atopic disease.
Nat Genet 29:175-8
[Abstract]
Abecasis GR, Cherny SS, Cookson WO and Cardon LR
(2001).
GRR: graphical representation of relationship errors.
Bioinformatics 17:742-3
[Abstract]
[PDF]
[Web]
Moffatt MF, Schou C, Faux JA, Abecasis GR, James A, Musk AW and Cookson WO
(2001).
Association between quantitative traits underlying asthma and the HLA-DRB1 locus in a family-based population sample.
Eur J Hum Genet 9:341-6
[Abstract]
Abecasis GR, Cookson WO and Cardon LR
(2001).
The power to detect linkage disequilibrium with quantitative traits in selected samples.
Am J Hum Genet 68:1463-74
[Abstract]
[PDF]
McKenzie CA, Abecasis GR, Keavney B, Forrester T, Ratcliffe PJ, Julier C, Connell JM, Bennett F, McFarlane-Anderson N, Lathrop GM and Cardon LR
(2001).
Trans-ethnic fine mapping of a quantitative trait locus for circulating angiotensin I-converting enzyme (ACE).
Hum Mol Genet 10:1077-84
[Abstract]
[PDF]
Abecasis GR, Cherny SS and Cardon LR
(2001).
The impact of genotyping error on family-based analysis of quantitative traits.
Eur J Hum Genet 9:130-4
[Abstract]
[PDF]
Cookson WO, Ubhi B, Lawrence R, Abecasis GR, Walley AJ, Cox HE, Coleman R, Leaves NI, Trembath RC, Moffatt MF and Harper JI
(2001).
Genetic linkage of childhood atopic dermatitis to psoriasis susceptibility loci.
Nat Genet 27:372-3
[Abstract]
[PDF]
Abecasis GR, Noguchi E, Heinzmann A, Traherne JA, Bhattacharyya S, Leaves NI, Anderson GG, Zhang Y, Lench NJ, Carey A, Cardon LR, Moffatt MF and Cookson WO
(2001).
Extent and distribution of linkage disequilibrium in three genomic regions.
Am J Hum Genet 68:191-197
[Abstract]
[PDF]
Cardon LR and Abecasis GR
(2000).
Regression models for association studies of quantitative trait loci in humans.
GeneScreen 1:55-57
[Abstract]
Cardon LR and Abecasis GR
(2000).
Some properties of a variance components model for fine-mapping quantitative trait loci.
Behav Genet 30:235-43
[Abstract]
[PDF]
Abecasis GR, Cookson WO and Cardon LR
(2000).
Pedigree tests of transmission disequilibrium.
Eur J Hum Genet 8:545-51
[Abstract]
[PDF]
[Web]
Moffatt MF, Traherne JA, Abecasis GR and Cookson WO
(2000).
Single nucleotide polymorphism and linkage disequilibrium within the TCR alpha/delta locus.
Hum Mol Genet 9:1011-1019
[Abstract]
[PDF]
Abecasis GR and Cookson WO
(2000).
GOLD--graphical overview of linkage disequilibrium.
Bioinformatics 16:182-3
[Abstract]
[PDF]
[Web]
Abecasis GR, Cardon LR and Cookson WO
(2000).
A General Test of Association for Quantitative Traits in Nuclear Families.
Am J Hum Genet 66:279-292
[Abstract]
[PDF]
[Web]
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